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Invitrogen
PRSS21 Polyclonal Antibody
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PRSS21 Antibody (PA5-47879) in IHC (F)
Immunohistochemical analysis of PRSS21 in perfusion fixed frozen sections of mouse testis. Samples were incubated in PRSS21 polyclonal antibody (Product # PA5-47879) using a dilution of 1.7 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown) and counterstained with hematoxylin (blue). Specific staining was localized to the plasma membranes of spermatocy... View More
产品信息
PA5-47879
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse,
Rat
已发表种属
Horse,
Mouse
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Mouse myeloma cell line NS0-derived recombinant mouse Testisin/Prss21 Gln28-Asn298
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody detects recombinant mouse Testisin/Prss21 in direct ELISAs and Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant mouse (rm) Prss8 and rmPrss27 is observed.
Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.
靶标信息
PRSS21, also known as testisin, is a serine protease gene located on human chromosome 16p13.3. This gene is primarily expressed in the testes, where it plays a significant role in spermatogenesis, particularly during the development and maturation of sperm cells. Structurally, PRSS21 encodes a glycosylphosphatidylinositol (GPI)-anchored serine protease, a feature that helps localize it to the cell surface, facilitating its involvement in cell signaling and proteolytic pathways. While research into PRSS21 remains ongoing, its specific function is believed to be related to remodeling the extracellular matrix during sperm development, impacting fertility. Beyond reproductive roles, alterations in PRSS21 expression have been observed in some cancer types, such as testicular germ cell tumors, suggesting its potential role as a biomarker for certain malignancies. This dual functionality underscores its importance not only in reproductive biology but also within oncology research.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: EC 3.4.21; eosinophil serine protease-1; protease, serine, 21; Serine protease 21; TEST1testisin; testicular serine protease 5; Testisin; Tryptase 4
基因别名: 1700023E12Rik; Esp-1; mT4; Prss21; Resp-1; TESP5; testisin
UniProt ID: (Mouse) Q9JHJ7
Entrez Gene ID: (Rat) 353251, (Mouse) 57256
