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Immunogen sequence: MASRYDRAIT VFSPDGHLFQ VEYAQEAVKK GSTAVGIRGT NIVVLGVEKK SVAKLQDERT VRKICALDDH VCMAFAVLTI FIGLTADARV VINRARVECQ SHKLTVEDPV TVEYITRFIA TLKQKYTQSN GRRPFGISAL IVGFDDDGIS RLYQTDPSGT YHAWKANAIG RSAKTVREFL EKNYTEDAIA SDSEAIKLAI KALLEVVQSG GKNIELAIIR RNQPLKMFSA KEVELYVTEI; Positive Samples: K-562, Mouse thymus, Mouse testis, Rat testis; Cellular Location: Cytoplasm, Nucleus
Component of the spermatoproteasome, a proteasome specifically found in testis that promotes acetylation-dependent degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. The proteasome is a protein complexe that degrades unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Required for 20S core proteasome assembly, essential for the degradation of meiotic proteins RAD51 and RPA1 at late prophase I and the progression of meiosis I during spermatogenesis. Localizes to the synaptonemal complex, a 'zipper'-like structure that holds homologous chromosome pairs in synapsis during meiotic prophase I. [UniProt]
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仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Alpha4s; proteasome (prosome, macropain) subunit, alpha type, 8; Proteasome alpha 4 subunit; proteasome alpha 8 subunit; proteasome subunit alpha type 7-like protein variant 1; proteasome subunit alpha type-7-like; Proteasome subunit alpha type-8; Proteasome subunit alpha-type 7-like; Proteasome subunit alpha-type 8
基因别名: 2410072D24Rik; PSMA7L; PSMA8; RGD1311659
UniProt ID: (Human) Q8TAA3, (Mouse) Q9CWH6
Entrez Gene ID: (Human) 143471, (Mouse) 73677, (Rat) 364814
分子生物学功能: protease