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Abnova
PSMB10 Monoclonal Antibody (3F8)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
H00005699-M01
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
3F8
抗原
PSMB10 (AAH17198, 1 a.a. approximately 273 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
See Label
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MLKPALEPRG GFSFENCQRN ASLERVLPGL KVPHARKTGT TIAGLVFQDG VILGADTRAT NDSVVADKSC EKIHFIAPKI YCCGAGVAAD AEMTTRMVAS KMELHALSTG REPRVATVTR ILRQTLFRYQ GHVGASLIVG GVDLTGPQLY GVHPHGSYSR LPFTALGSGQ DAALAVLEDR FQPNMTLEAA QGLLVEAVTA GILGDLGSGG NVDACVITKT GAKLLRTLSS PTEPVKRSGR YHFVPGTTAV LTQTVKPLTL ELVEETVQAM EVE
靶标信息
The 20S proteasome is a protease complex that is responsible for cytosolic protein degradation and generation of peptide ligands for major histocompatibility complex (MHC) class I molecules, either in their final form or in the form of amino-terminally extended precursors. Upon IFN-gamma stimulation of cells, three constitutively expressed subunits of the 20S proteasome are replaced by inducible subunits LMP2 (low-molecular mass polypeptide 2), LMP7, and MECL-1 (multicatalytic endopeptidase complex-like-1, LMP10). LMP2, LMP7, and MECL-1 subunits form immunoproteasomes, which are associated with more efficient class I antigen processing and presentation. Independent assortment of LMP-2, LMP-7, and MECL-1 into different proteasome complexes can lead to 36 unique proteasome subsets, which may mediate differences in the cleavage specificities/cleavage motifs of proteins subject to constitutive- and immuno-proteasomes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: low molecular mass protein 10; macropain subunit MECl-1; MGC1665; multicatalytic endopeptidase complex subunit MECl-1; OTTHUMP00000174858; proteasome (prosome, macropain) subunit, beta type, 10; proteasome catalytic subunit 2i; Proteasome MECl 1; proteasome MECl-1; proteasome subunit beta 10; proteasome subunit beta 7i; proteasome subunit beta-2i; proteasome subunit beta2i; proteasome subunit MECL1; PSMB 10; PSMB10; unnamed protein product
基因别名: beta2i; IMD121; LMP10; MECL1; PRAAS5
UniProt ID: (Human) P40306
Entrez Gene ID: (Human) 5699
immune system process
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
humoral immune response
proteasomal protein catabolic process
proteasomal ubiquitin-independent protein catabolic process
protein catabolic process
positive regulation of interferon-gamma production
positive regulation of interleukin-2 production
positive regulation of tumor necrosis factor production
response to interferon-gamma
proteasome-mediated ubiquitin-dependent protein catabolic process
CD8-positive, alpha-beta T cell differentiation
thymic T cell selection
T-helper 1 cell differentiation
negative regulation of regulatory T cell differentiation
T-helper 17 cell differentiation
CD8-positive, alpha-beta T cell homeostasis
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