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Invitrogen
PSMD14 Polyclonal Antibody
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产品信息
PA5-88037
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 160-300 of human PSMD14 (NP_0057961)
偶联物
形式
Liquid
浓度
2.37 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: FRLINANMMV LGHEPRQTTS NLGHLNKPSI QALIHGLNRH YYSITINYRK NELEQKMLLN LHKKSWMEGL TLQDYSEHCK HNESVVKEML ELAKNYNKAV EEEDKMTPEQ LAIKNVGKQD PKRHLEEHVD VLMTSNIVQC L; Positive Samples: HepG2, HeLa, A-549, 293T, Raji, Mouse heart, Mouse kidney, Mouse liver
靶标信息
The 26S proteasome is responsible for most intracellular proteolysis in eukaryotes. POH1 (also known as Rpn11 in yeast) subunit of the 19S complex is responsible for substrate deubiquitination during proteasomal degradation. POH1 appears to be a Zn21-dependent protease, unlike all other known deubiquitinating enzymes (DUBs) that are cysteine proteases. POH1 was first identified as the human functional homolog of the S. pombe pad1 gene, which confers moderate resistance to chemotherapeutic drugs, and also to ultraviolet light when transiently overproduced in mammalian cells. Poh1-induced drug resistance is mediated through AP-1 transcription factors.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 26S proteasome non-ATPase regulatory subunit 14; 26S proteasome non-ATPase subunit; 26S proteasome regulatory subunit RPN11; 26S proteasome-associated pad1 homolog; 26S proteasome-associated PAD1 homolog 1; MAD1; proteasome (prosome, macropain) 26S subunit, non-ATPase, 14; proteasome 26S subunit, non-ATPase 14; testis tissue sperm-binding protein Li 69n
基因别名: 2610312C03Rik; 3200001M20Rik; AA986732; PAD1; POH1; PSMD14; rpm11; RPN11
UniProt ID: (Human) O00487, (Mouse) O35593
Entrez Gene ID: (Human) 10213, (Rat) 311078, (Mouse) 59029
MAPK cascade
protein polyubiquitination
double-strand break repair via homologous recombination
stimulatory C-type lectin receptor signaling pathway
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
double-strand break repair via nonhomologous end joining
ubiquitin-dependent protein catabolic process
regulation of cellular amino acid metabolic process
positive regulation of endopeptidase activity
anaphase-promoting complex-dependent catabolic process
tumor necrosis factor-mediated signaling pathway
NIK/NF-kappaB signaling
Fc-epsilon receptor signaling pathway
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of mRNA stability
response to ethanol
T cell receptor signaling pathway
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
Wnt signaling pathway, planar cell polarity pathway
regulation of proteasomal protein catabolic process
protein K63-linked deubiquitination
negative regulation of canonical Wnt signaling pathway
positive regulation of canonical Wnt signaling pathway
DNA repair
proteolysis
cellular response to DNA damage stimulus
