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Invitrogen
PSRC1 Polyclonal Antibody
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产品信息
PA5-66023
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: NRLAAQLEQCA LQDRESAGEG LGPRRVKPSP RRETFVLKDS PVRDLLPTVN SLTRSTPSPS SLTPRLRSND RKGSVRALRA TSGKRPSNMK R
Highest antigen sequence identity to the following orthologs - mouse 70%, rat 67%.
靶标信息
PSRC1 is required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: differential display and activated by p53; MGC1780; OTTHUMP00000013785; OTTHUMP00000013786; p53-regulated DDA3; proline/serine-rich coiled-coil 1; Proline/serine-rich coiled-coil protein 1
基因别名: DDA3; FP3214; PSRC1
UniProt ID: (Human) Q6PGN9
Entrez Gene ID: (Human) 84722
microtubule bundle formation
mitotic metaphase plate congression
negative regulation of cell growth
positive regulation of microtubule polymerization
positive regulation of cyclin-dependent protein serine/threonine kinase activity
positive regulation of transcription, DNA-templated
cell division
regulation of mitotic spindle organization
