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PTCH Polyclonal Antibody

查看其他25个PTCH抗体

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PTCH Polyclonal Antibody

产品信息

PA5-142733

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1-3 µg/mL
-

免疫组化（石蜡） (IHC (P))

8 µg/mL
-

免疫细胞化学 (ICC/IF)

5 µg/mL
-
产品规格

种属反应

Human, Mouse

宿主/亚型

Goat / IgG

分类

Polyclonal

类型

Antibody

抗原

Peptide with sequence C-EELKKINYQVDSWEE.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Ammonium sulfate precipitation

保存液

TBS, pH 7.3, with 0.5% BSA

内含物

0.02% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2933379

产品详细信息

Additional Information: This antibody is expected to recognize all reported isoforms (NP_000255.2; NP_001077072.1; NP_001077071.1; NP_001077073.1).

This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.

靶标信息

This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: etID309849.2; FLJ26746; FLJ42602; HGNC:9585; mesenchymal dysplasia; OTTHUMP00000021709; OTTHUMP00000021710; patched; Patched 1; patched gene homolog; similar to Drosophila patched protein, Swiss-Prot Accession Number P18502; transmembrane protein; Method: conceptual translation supplied by author; patched1; Protein patched homolog 1; PTC; ptc-1; PTCH protein -3; Ptch1 protein +12b; RP11-435O5.3; unnamed protein product

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基因别名: A230106A15Rik; BCNS; BCNS1; mes; NBCCS; PTC; PTC1; PTCH; PTCH1; SLC65B1

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UniProt ID: (Human) Q13635, (Mouse) Q61115

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Entrez Gene ID: (Human) 5727, (Mouse) 19206

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功能
patched binding smoothened binding protein binding hedgehog receptor activity heparin binding cholesterol binding cyclin binding macromolecular complex binding hedgehog family protein binding zinc ion binding protein complex binding
参与通路
negative regulation of transcription from RNA polymerase II promoter branching involved in ureteric bud morphogenesis in utero embryonic development cell fate determination neural tube formation neural tube closure heart morphogenesis signal transduction spermatid development regulation of mitotic cell cycle pattern specification process brain development negative regulation of cell proliferation epidermis development regulation of smoothened signaling pathway response to xenobiotic stimulus response to mechanical stimulus organ morphogenesis dorsal/ventral pattern formation epidermal cell fate specification response to chlorate negative regulation of keratinocyte proliferation positive regulation of cholesterol efflux protein processing spinal cord motor neuron differentiation neural tube patterning dorsal/ventral neural tube patterning neural plate axis specification embryonic limb morphogenesis prostate gland development mammary gland development response to estradiol response to retinoic acid regulation of protein localization limb morphogenesis hindlimb morphogenesis regulation of growth negative regulation of multicellular organism growth regulation of cell proliferation glucose homeostasis response to alkaloid keratinocyte proliferation positive regulation of epidermal cell differentiation negative regulation of osteoblast differentiation negative regulation of smoothened signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated embryonic organ development smooth muscle tissue development epithelial cell proliferation negative regulation of epithelial cell proliferation negative regulation of cell division pharyngeal system development mammary gland duct morphogenesis mammary gland epithelial cell differentiation cell differentiation involved in kidney development somite development cellular response to cholesterol commissural neuron axon guidance stem cell proliferation cell proliferation involved in metanephros development metanephric collecting duct development protein localization to plasma membrane liver regeneration negative regulation of stem cell proliferation smoothened signaling pathway negative regulation of sequence-specific DNA binding transcription factor activity smoothened signaling pathway involved in dorsal/ventral neural tube patterning protein targeting to plasma membrane
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