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PTF1A Antibody (711100) in WB
Western blot analysis was performed on tissue extracts (30 µg of lysate) of Mouse brain (Lane 1), Rat brain (Lane 2), Mouse pancreas (Lane 3), Rat pancreas (Lane 4) and whole cell extracts of Jurkat (Lane 5). The blots were probed with Anti-PTF1A Recombinant Rabbit Superclonal™ Antibody (Product # 711100, 1-2 µg/mL) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, HRP conjugate (Product # A27036, 0.4 µg/mL, 1:2500 dilution). A ~ 50 kDa band corresponding to PTF1A was observed in th... View More
产品信息
711100
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Superclonal
类型
Antibody
克隆号
12 HCLC
抗原
Protein corresponding to Human PTF1A (aa 1-328)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.2
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
This antibody is predicted to react with Monkey, Pig, Bovine and Rat
Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit Superclonal™ antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production. Note: Formerly called “Recombinant polyclonal antibody”, this product is now rebranded as “Recombinant Superclonal™ antibody”. The physical product and the performance remain unchanged.
靶标信息
PFT1A is a component of the pancreas transcription factor 1 complex and is known to have a role in mammalian pancreatic development. The protein plays a role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. The protein is thought to be involved in the maintenance of exocrine pancreas-specific gene expression including elastase 1 and amylase. Mutations in this gene cause cerebellar agenesis and loss of expression is seen in ductal type pancreas cancers.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: bHLH transcription factor p48; bHLHa29; Class A basic helix-loop-helix protein 29; class II bHLH protein PTF1A; exocrine pancreas-specific transcription factor p48; p48 DNA-binding subunit of transcription factor PTF1; Pancreas transcription factor 1 subunit alpha; pancreas transcription factor1 p48 subunit; Pancreas-specific transcription factor 1a; PTF1-p48
基因别名: BHLHA29; PACA; PAGEN2; PTF1-p48; PTF1A; PTF1P48
UniProt ID: (Human) Q7RTS3, (Rat) Q64305, (Mouse) Q9QX98
Entrez Gene ID: (Human) 256297, (Rat) 117034, (Mouse) 19213
RNA polymerase II distal enhancer sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
chromatin binding
protein dimerization activity
E-box binding
transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
protein binding
basic helix-loop-helix transcription factor
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
embryo development
tissue development
retina layer formation
cerebellum development
pancreas development
exocrine pancreas development
amacrine cell differentiation
positive regulation of transcription from RNA polymerase II promoter
retinoic acid receptor signaling pathway
neuron fate commitment
regulation of neural retina development
transcription, DNA-templated
cell differentiation
hindbrain development
cell fate commitment
positive regulation of transcription, DNA-templated
generation of neurons
retina morphogenesis in camera-type eye
multicellular organism development
nervous system development
