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PTH1R (extracellular) Antibody (APR-051-200UL) in ICC/IF
Expression of Parathyroid hormone receptor 1 in rat U-87 MG cells - Cell surface detection of Parathyroid hormone receptor 1in intact living rat U-87 MG cells. A. Extracellular staining of cells using Anti-PTH1R (extracellular) Antibody (#APR-051), (1:50), (green). B. Merge of A with live view of the cells.
产品信息
APR-051-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)DAVLYSGFTLDEAER, corresponding to amino acid residues 241-255 of rat PTH1R, 1st extracellular loop
偶联物
形式
Lyophilized
浓度
0.85 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Parathyroid hormone receptor 1 is a member of the G-protein coupled receptor family. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Parathyroid hormone receptor 1 has been reported to be expressed in bone, breast, brain, colon, GI, kidney, liver, placenta, skin, umbilical cord, and uterus.
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生物信息学
蛋白别名: MGC138426; MGC138452; Parathyroid hormone 1 receptor; parathyroid hormone receptor; parathyroid hormone receptor 1; Parathyroid hormone/parathyroid hormone-related peptide receptor; parathyroid hormone/parathyroid hormone-related protein receptor; PTH-related peptide receptor; PTH/PTHr receptor; PTH/PTHrP receptor; PTH/PTHrP type I receptor; PTH1 receptor; PTHrP-R; PTHrP-receptor; seven transmembrane helix receptor
基因别名: PFE; PPR; PTH1R; PTHR; PTHR1; PTHrel
UniProt ID: (Human) Q03431, (Rat) P25961, (Mouse) P41593
Entrez Gene ID: (Human) 5745, (Rat) 56813, (Mouse) 19228
skeletal system development
chondrocyte differentiation
osteoblast development
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
aging
positive regulation of cell proliferation
negative regulation of cell proliferation
bone mineralization
bone resorption
cell maturation
positive regulation of inositol phosphate biosynthetic process
ossification
cellular calcium ion homeostasis
signal transduction
