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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • PYK2 Antibodies

          Abnova

          PTK2B Monoclonal Antibody (X1)

          查看其他34个PYK2抗体

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          说明书
          实验方案
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          技术支持
          说明书
          实验方案
          问题与答案
          技术支持

          Cite PTK2B Monoclonal Antibody (X1)

          • 抗体检测数据 (1)
          PTK2B Antibody in Western Blot (WB)
          Group 53 Created with Sketch.
          PTK2B Antibody in Western Blot (WB)
          Group 53 Created with Sketch.

          图: 1 / 1

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          PTK2B Antibody (H00002185-M03) in WB

          PTK2B monoclonal antibody (M03), clone X1. Western Blot analysis of PTK2B expression in K-562. {{ $ctrl.currentElement.advancedVerification.fullName }} 验证信息 View more
          已发表图片由___提供 benchsci-logo
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          PTK2B Antibody in Western Blot (WB)
          PTK2B Monoclonal Antibody (X1)

          产品信息

          H00002185-M03

          应用
          建议稀释比
          已发表文章

          免疫印迹 (WB)

          1-5 µg/mL
          -

          酶联免疫吸附实验 (ELISA)

          10 µg/mL
          -
          产品规格

          种属反应

          Human

          宿主/亚型

          Mouse / IgG2a, kappa

          分类

          Monoclonal

          类型

          Antibody

          克隆号

          X1

          抗原

          PTK2B (AAH36651, 682 a.a. approximately 871 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
          查看免疫原

          偶联物

          Unconjugated Unconjugated Unconjugated

          形式

          Liquid

          浓度

          0.46 mg/mL

          纯化类型

          Protein A

          保存液

          PBS, pH 7.4

          内含物

          no preservative

          保存条件

          -20°C, Avoid Freeze/Thaw Cycles

          运输条件

          Ambient (domestic); Wet ice (international)

          产品详细信息

          Product may be used with Western Blot (Cell lysate).

          Immunogen sequence: VYQMEKDIAM EQERNARYRT PKILEPTAFQ EPPPKPSRPK YRPPPQTNLL APKLQFQVPE GLCASSPTLT SPMEYPSPVN SLHTPPLHRH NVFKRHSMRE EDFIQPSSRE EAQQLWEAEK VKMRQILDKQ QKQMVEDYQW LRQEEKSLDP MVYMNDKSPL TPEKEVGYLE FTGPPQKPPR LGAQSIQPTA

          靶标信息

          PTK2B (FAK2) is a cytoplasmic tyrosine kinase involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. PTK2B regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading, and bone remodeling. FAK2 plays a role in the regulation of the humoral immune response and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. It functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors, cytokine, chemokine, and growth factor receptors, and mediates responses to cellular stress. Aberrant FAK2 expression may play a role in cancer cell proliferation, migration, and invasion in tumor formation and metastasis. Elevated expression has been seen in gliomas, hepatocellular carcinoma, lung cancer, and breast cancer.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

          篇参考文献 (0)

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          引用该产品

          生物信息学

          蛋白别名: CADTK; CAK-beta; Calcium-dependent tyrosine kinase; Calcium-regulated non-receptor proline-rich tyrosine kinase; Cell adhesion kinase beta; FADK; FADK 2; FAK; FAK1; Focal adhesion kinase 2; FRNK; pp125FAK; Proline-rich tyrosine kinase 2; protein kinase B; Protein-tyrosine kinase 2-beta; PTK2B protein tyrosine kinase 2 beta; RAFTK; Related adhesion focal tyrosine kinase

          查看更多 收起

          基因别名: CADTK; CAKB; FADK2; FAK2; PKB; PTK; PTK2B; PYK2; RAFTK

          查看更多 收起

          UniProt ID: (Human) Q14289

          查看更多 收起

          Entrez Gene ID: (Human) 2185

          查看更多 收起

          功能
          calmodulin-dependent protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity signal transducer activity NMDA glutamate receptor activity receptor binding protein binding ATP binding protein complex binding 3-phosphoinositide-dependent protein kinase binding
          参与通路
          MAPK cascade angiogenesis oocyte maturation response to hypoxia positive regulation of cell-matrix adhesion sprouting angiogenesis adaptive immune response marginal zone B cell differentiation protein complex assembly protein phosphorylation apoptotic process response to stress cellular defense response response to osmotic stress signal transduction cell surface receptor signaling pathway signal complex assembly epidermal growth factor receptor signaling pathway positive regulation of cytosolic calcium ion concentration integrin-mediated signaling pathway positive regulation of cell proliferation negative regulation of cell proliferation regulation of cell shape response to mechanical stimulus response to hormone response to glucose response to lithium ion positive regulation of endothelial cell migration negative regulation of muscle cell apoptotic process regulation of cGMP-mediated signaling regulation of macrophage chemotaxis positive regulation of neuron projection development glial cell proliferation peptidyl-tyrosine phosphorylation regulation of cell adhesion positive regulation of cell growth positive regulation of cell migration negative regulation of bone mineralization regulation of cGMP biosynthetic process positive regulation of actin filament polymerization neuron projection development regulation of inositol trisphosphate biosynthetic process tumor necrosis factor-mediated signaling pathway ionotropic glutamate receptor signaling pathway response to immobilization stress peptidyl-tyrosine autophosphorylation response to cocaine response to drug response to hydrogen peroxide activation of Janus kinase activity negative regulation of apoptotic process stress fiber assembly negative regulation of potassium ion transport positive regulation of JUN kinase activity negative regulation of neuron apoptotic process blood vessel endothelial cell migration positive regulation of phosphatidylinositol 3-kinase activity innate immune response positive regulation of nitric oxide biosynthetic process bone resorption response to ethanol negative regulation of myeloid cell differentiation positive regulation of translation positive regulation of angiogenesis positive regulation of protein kinase activity positive regulation of JNK cascade protein autophosphorylation vascular endothelial growth factor receptor signaling pathway focal adhesion assembly positive regulation of peptidyl-tyrosine phosphorylation regulation of calcium-mediated signaling positive regulation of nitric-oxide synthase activity regulation of release of sequestered calcium ion into cytosol response to cAMP response to calcium ion positive regulation of synaptic transmission, glutamatergic long-term synaptic potentiation long term synaptic depression chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade cellular response to retinoic acid cellular response to fluid shear stress activation of GTPase activity regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process regulation of establishment of cell polarity regulation of actin cytoskeleton reorganization regulation of N-methyl-D-aspartate selective glutamate receptor activity positive regulation of excitatory postsynaptic potential positive regulation of B cell chemotaxis positive regulation of DNA biosynthetic process
          It has to be done as per old AB suggested Products section.
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