Search

  • 联系我们
  • 货号直购

Invitrogen

PTP1B/PTPN2 Recombinant Rabbit Monoclonal Antibody (5H9)

查看其他3个PTP1B/PTPN2抗体

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

说明书
证书
实验方案
问题与答案
技术支持
说明书
证书
实验方案
问题与答案
技术支持
说明书
证书
实验方案
问题与答案
技术支持
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}

产品信息

MA573280

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-

流式细胞分析 (Flow)

1:50-1:100
-

免疫沉淀 (IP)

1:20-1:50
-
产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

5H9

抗原

KLH conjugated synthetic peptide derived from human PTPN1.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.25 mg/mL

规格

25 µg

纯化类型

Protein A

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

PTP1B (Protein Tyrosine Phosphatase 1B), encoded by the PTPN1 gene located on chromosome 20q13.1, is a major regulator of several cellular signaling pathways, impacting diseases like diabetes, obesity, and various cancers. The protein structure includes multiple exons and functions as a non-transmembrane enzyme that negatively regulates signaling cascades, including insulin and leptin signaling, which are vital for metabolic homeostasis. PTPN2 (Protein Tyrosine Phosphatase Non-Receptor Type 2), located on chromosome 18p11.3-p11.2, also known as T-cell PTP, is similarly a non-transmembrane protein tyrosine phosphatase that modulates immune responses and cell growth. It has ten exons and produces two splice variants, impacting signaling pathways by regulating the phosphorylation state of key proteins. Both of these phosphatases are involved in the fine-tuning of signaling mechanisms that control cell growth, differentiation, and immune regulation, highlighting their importance in disease pathology and as potential therapeutic targets.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

篇参考文献 (0)

您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
引用该产品

生物信息学

蛋白别名: MPTP; phosphotyrosyl-protein phosphatase (EC 3.1.3.48); protein tyrosine phosphatase 1B; protein tyrosine phosphatase, placental; protein-protein-tyrosine phosphatase HA2; Protein-tyrosine phosphatase 1B; Protein-tyrosine phosphatase HA2; Protein-tyrosine phosphatase PTP-2; PTP-1B; PTP-HA2; PTP1B; T cell protein-tyrosine phosphatase; T-cell protein tyrosine phosphatase; T-cell protein-tyrosine phosphatase; TCPTP; Tyrosine-protein phosphatase non-receptor type 1; Tyrosine-protein phosphatase non-receptor type 2; unnamed protein product

查看更多 收起

基因别名: AI325124; PTN2; PTP-1B; PTP-HA2; PTP1B; PTPN1; PTPN2; PTPT; TC-PTP; TC45; TC48; TCELLPTP; TCPTP

查看更多 收起

UniProt ID: (Human) P18031, (Human) P17706, (Mouse) P35821, (Mouse) Q06180

查看更多 收起

Entrez Gene ID: (Human) 5770, (Human) 5771, (Mouse) 19246, (Mouse) 19255

查看更多 收起

功能
RNA binding phosphoprotein phosphatase activity protein tyrosine phosphatase activity non-membrane spanning protein tyrosine phosphatase activity insulin receptor binding protein binding zinc ion binding hydrolase activity phosphatase activity enzyme binding protein kinase binding receptor tyrosine kinase binding cadherin binding ephrin receptor binding protein phosphatase 2A binding integrin binding syntaxin binding STAT family protein binding poly(A) RNA binding protein phosphatase
参与通路
positive regulation of systemic arterial blood pressure protein dephosphorylation negative regulation of cell proliferation insulin receptor signaling pathway regulation of signal transduction negative regulation of signal transduction positive regulation of heart rate positive regulation of cardiac muscle cell apoptotic process negative regulation of cell-substrate adhesion negative regulation of neuron projection development actin cytoskeleton organization regulation of endocytosis regulation of proteolysis negative regulation of vascular endothelial growth factor receptor signaling pathway endoplasmic reticulum unfolded protein response response to nutrient levels cellular response to insulin stimulus regulation of intracellular protein transport cellular response to unfolded protein response to endoplasmic reticulum stress peptidyl-tyrosine dephosphorylation platelet-derived growth factor receptor-beta signaling pathway cellular response to platelet-derived growth factor stimulus IRE1-mediated unfolded protein response insulin receptor recycling negative regulation of MAP kinase activity cellular response to fibroblast growth factor stimulus positive regulation of JNK cascade regulation of insulin receptor signaling pathway negative regulation of insulin receptor signaling pathway negative regulation of protein kinase B signaling regulation of type I interferon-mediated signaling pathway JAK-STAT cascade involved in growth hormone signaling pathway negative regulation of ERK1 and ERK2 cascade cellular response to hypoxia cellular response to nitric oxide vascular endothelial cell response to oscillatory fluid shear stress regulation of postsynapse assembly regulation of hepatocyte growth factor receptor signaling pathway negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of IRE1-mediated unfolded protein response negative regulation of PERK-mediated unfolded protein response cellular response to angiotensin negative regulation of vascular associated smooth muscle cell migration cellular response to nerve growth factor stimulus response to angiotensin positive regulation of endothelial cell apoptotic process positive regulation of receptor catabolic process negative regulation of transcription from RNA polymerase II promoter negative regulation of tumor necrosis factor-mediated signaling pathway negative regulation of lipid storage B cell differentiation T cell differentiation erythrocyte differentiation negative regulation of epidermal growth factor receptor signaling pathway negative regulation of tyrosine phosphorylation of STAT protein glucose homeostasis negative regulation of macrophage differentiation positive regulation of gluconeogenesis negative regulation of JAK-STAT cascade negative regulation of inflammatory response negative regulation of T cell receptor signaling pathway negative regulation of chemotaxis regulation of interferon-gamma-mediated signaling pathway negative regulation of interferon-gamma-mediated signaling pathway negative regulation of type I interferon-mediated signaling pathway negative regulation of interleukin-6-mediated signaling pathway negative regulation of interleukin-2-mediated signaling pathway negative regulation of interleukin-4-mediated signaling pathway negative regulation of macrophage colony-stimulating factor signaling pathway negative regulation of positive thymic T cell selection positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of PERK-mediated unfolded protein response negative regulation of platelet-derived growth factor receptor-beta signaling pathway activation of JUN kinase activity dephosphorylation actin cytoskeleton reorganization positive regulation of protein tyrosine kinase activity peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity negative regulation of tyrosine phosphorylation of Stat3 protein negative regulation of tyrosine phosphorylation of Stat5 protein negative regulation of tyrosine phosphorylation of Stat6 protein negative regulation of protein tyrosine kinase activity negative regulation of prolactin signaling pathway
guarantee_icon

性能保障

只要您发现Invitrogen抗体在实验中的表现与网站或说明书的所述内容不符，您即可享受免费退换货服务。*

了解更多
help_icon

随时为您服务

获取常见问题的专家解答，或者直接联系我们的技术专家，咨询应用、设备、常规产品使用问题。

联系技术支持