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Invitrogen
PTPN22 Polyclonal Antibody
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PTPN22 Antibody (PA5-99219) in ICC/IF
Immunofluorescent analysis of PTPN22 in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and PTPN22 polyclonal antibody (Product # PA5-99219) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
产品信息
PA5-99219
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human PTPN22(Accession Q9Y2R2), corresponding to amino acid residues K770-I807.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total PTPN22.
靶标信息
The protein tyrosine phosphatase PTPN22 (PTP22, LYP, PEP, formerly PTPN8) is a genetic variant that confers risk of developing diverse human autoimmune diseases such as type 1 diabetes and rheumatoid arthritis. The minor allele of a missense SNP in PTPN22 encodes a hematopoietic-specific protein tyrosine phosphatase also known as "Lyp." The risk allele is present in about 17% of Caucasian individuals from the general population and in approximately 28% of Caucasian individuals with rheumatoid arthritis; it is thought to disrupt the P1 proline-rich motif that is important for interaction with the Src homology-3 (SH3) domain of CSK (cytoplasmic tyrosine kinase), potentially altering the normal functions of these proteins as negative regulators of T cell activation. The interaction between CSK and PTPN22 is highly specific and it is speculated that PTPN22 may be an effector and/or regulator of CSK in T cells and other hematopoietic cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP; Lymphoid phosphatase; lymphoid-specific protein tyrosine phosphatase; LyP; PEP; PEST domain-enriched tyrosine phosphatase; PEST-domain phosphatase; protein tyrosine phosphatase, non-receptor type 22 (lymphoid); protein tyrosine phosphatase, non-receptor type 8; tyrosine-phosphatase; Tyrosine-protein phosphatase non-receptor type 22
基因别名: 70zpep; LYP; LYP1; LYP2; PEP; PTPN22; PTPN8
UniProt ID: (Human) Q9Y2R2, (Mouse) P29352
Entrez Gene ID: (Human) 26191, (Rat) 295338, (Mouse) 19260
protein dephosphorylation
biological_process
T cell differentiation
regulation of natural killer cell proliferation
peptidyl-tyrosine dephosphorylation
phosphoanandamide dephosphorylation
T cell receptor signaling pathway
regulation of T cell receptor signaling pathway
negative regulation of T cell receptor signaling pathway
negative regulation of T cell activation
immune system process
autophagy
dephosphorylation
negative regulation of autophagy
positive regulation of gene expression
negative regulation of gene expression
lipopolysaccharide-mediated signaling pathway
positive regulation of type I interferon production
response to lipopolysaccharide
negative regulation of tumor necrosis factor production
positive regulation of toll-like receptor 3 signaling pathway
positive regulation of toll-like receptor 4 signaling pathway
negative regulation of JUN kinase activity
regulation of innate immune response
regulation of B cell receptor signaling pathway
positive regulation of ERK1 and ERK2 cascade
negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
cellular response to muramyl dipeptide
negative regulation of interleukin-6 secretion
regulation of NIK/NF-kappaB signaling
positive regulation of protein K63-linked ubiquitination
positive regulation of interferon-gamma secretion
negative regulation of p38MAPK cascade
negative regulation of interleukin-8 secretion
