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Invitrogen
PTPRD Polyclonal Antibody
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PTPRD Antibody (PA5-90641) in WB
Western blot analysis of PTPRD in extracts of various cell lines. Samples were incubated with PTPRD Polyclonal antibody (Product # PA5-90641) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 3 min.
产品信息
PA5-90641
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1100-1265 of human PTPRD (NP_0028301)
偶联物
形式
Liquid
浓度
2.64 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: TAKTAPDVLR TKPAFIGKTN LDGMITVQLP EVPANENIKG YYIIIVPLKK SRGKFIKPWE SPDEMELDEL LKEISRKRRS IRYGREVELK PYIAAHFDVL PTEFTLGDDK HYGGFTNKQL QSGQEYVFFV LAVMEHAESK MYATSPYSDP VVSMDLDPQP ITDEEE; Positive Samples: 293T, OVCAR3, Raji, Mouse brain, Mouse kidnay, Mouse heart, Rat brain; Cellular Location: Membrane, Single-pass type I membrane protein
靶标信息
PTPRD is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: protein tyrosine phosphatase, receptor type, D; protein tyrosine phosphatase, receptor type, delta polypeptide; Protein-tyrosine phosphatase delta; R-PTP-delta; Receptor-type tyrosine-protein phosphatase delta
基因别名: 1110002J03Rik; 3000002J10Rik; B230219D21Rik; HPTP; HPTPD; HPTPDELTA; PTPD; PTPRD; R-PTP-delta; RPTPDELTA
UniProt ID: (Human) P23468, (Mouse) Q64487
Entrez Gene ID: (Human) 5789, (Mouse) 19266, (Rat) 313278
protein dephosphorylation
phosphate-containing compound metabolic process
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
transmembrane receptor protein tyrosine phosphatase signaling pathway
chemical synaptic transmission
neuron differentiation
peptidyl-tyrosine dephosphorylation
positive regulation of dendrite morphogenesis
presynaptic membrane assembly
dephosphorylation
negative regulation of JAK-STAT cascade
regulation of immune response
