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Abnova
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Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MGPPLPLLLL LLLLLPPRVL PAAPSSVPRG RQLPGRLGCL LEEGLCGASE ACVNDGVFGR CQKVPAMDFY RYEVSPVALQ RLRVALQKLS GTGFTWQDDY TQYVMDQELA DLPKTYLRRP EASSPARPSK HSVGSERRYS REGGAALANA LRRHLPFLEA LSQAPASDVL ARTHTAQDRP PAEGDDRFSE SILTYVAHTS ALTYPPGPRT QLREDLLPRT LGQLQPDELS PKVDSGVDRH HLMAALSAYA AQRPPAPPGE GSLEPQYLLR APSRMPRPLL APAAPQKWPS PLGDSEDPSS TGDGARIHTL LKDLQRQPAE VRGLSGLELD GMAELMAGLM QGVDHGVARG SPGRAALGES GEQADGPKAT LRGDSFPDDG VQDDDDRLYQ EVHRLSATLG GLLQDHGSRL LPGALPFARP LDMERKKSEH PESSLSSEEE TAGVENVKSQ TYSKDLLGQQ PHSEPGAAAF GELQNQMPGP SKEEQSLPAG AQEALSDGLQ LEVQPSEEEA RGYIVTDREV LGPAVTFKVS ANVQNVTTED VEKATVDNKD KLEETSGLKI LQTGVGSKSK LKFLPPQAEQ EDSTKFIALT LVSLACILGV LLASGLIYCL RHSSQHRLKE KLSGLGGDPG ADATAAYQEL CRQRMATRPP DRPEGPHTSR ISSVSSQFSD GPIPSPSARS SASSWSEEPV QSNMDISTGH MILSYMEDHL KNKNRLEKEW EALCAYQAEP NSSFVAQREE NVPKNRSLAV LTYDHSRVLL KAENSHSHSD YINASPIMDH DPRNPAYIAT QGPLPATVAD FWQMVWESGC VVIVMLTPLA ENGVRQCYHY WPDEGSNLYH IYEVNLVSEH IWCEDFLVRS FYLKNLQTNE TRTVTQFHFL SWYDRGVPSS SRSLLDFRRK VNKCYRGRSC PIIVHCSDGA GRSGTYVLID MVLNKMAKGA KEIDIAATLE HLRDQRPGMV QTKEQFEFAL TAVAEEVNAI LKALPQ
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus. Three alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: EC 3.1.3.48; IAR; IAR/receptor-like protein-tyrosine phosphatase; Islet cell autoantigen-related protein; Phogrin; protein tyrosine phosphatase receptor pi; protein tyrosine phosphatase, receptor type, N polypeptide 2; R-PTP-N2; Receptor-type tyrosine-protein phosphatase N2; tyrosine phosphatase IA-2 beta
基因别名: IA-2beta; IAR; ICAAR; KIAA0387; PTPRN2; PTPRP; R-PTP-N2
UniProt ID: (Human) Q92932
Entrez Gene ID: (Human) 5799