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Invitrogen
PTPRZ Polyclonal Antibody
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Product Details
PA5-101832
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
C. elegans,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human PTPRZ1(Accession P23471), corresponding to amino acid residues F121-K171.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total PTPRZ1.
Target Information
Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 3F8 chondroitin sulfate proteoglycan; 3H1 keratan sulfate proteoglycan; 6B4 proteoglycan; Phosphacan; protein tyrosine phosphatase, receptor-type, Z polypeptide 1; protein tyrosine phosphatase, receptor-type, zeta polypeptide 1; protein tyrosine phosphate, receptor type, Z; Protein-tyrosine phosphatase receptor type Z polypeptide 1; Protein-tyrosine phosphatase receptor type Z polypeptide 2; PTP zeta; R-PTP-zeta; R-PTP-zeta-2; receptor-type tyrosine phosphatase beta/zeta; Receptor-type tyrosine-protein phosphatase zeta
Gene Aliases: AI850339; DSD-1-PG; HPTPZ; HPTPzeta; HTPZP2; phosphacan; PTP-ZETA; PTP18; PTPbeta; PTPRZ; PTPRZ1; PTPRZ2; PTPZ; PTPzeta; PTPzeta-A; PTPzeta-B; PTPzeta-S; R-PTP-zeta-2; RPTPB; RPTPbeta; RPTPz
UniProt ID: (Human) P23471, (Mouse) B9EKR1, (Rat) Q62656
Entrez Gene ID: (Human) 5803, (Mouse) 19283, (Rat) 25613
hematopoietic progenitor cell differentiation
protein dephosphorylation
axonogenesis
axonal fasciculation
central nervous system development
learning or memory
negative regulation of cell proliferation
visual learning
negative regulation of cell-substrate adhesion
hippocampus development
peptidyl-tyrosine dephosphorylation
positive regulation of fibroblast proliferation
oligodendrocyte differentiation
regulation of dendrite morphogenesis
positive regulation of peptidyl-tyrosine phosphorylation
regulation of oligodendrocyte progenitor proliferation
positive regulation of dendrite development
positive regulation of Schwann cell migration
positive regulation of neuron death
negative regulation of dendrite development
positive regulation of neuron migration
positive regulation of neuron projection development
dephosphorylation
positive regulation of cell migration
brain development
neuron development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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