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Invitrogen
PURB Polyclonal Antibody
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PURB Antibody (PA5-110245) in WB
Western blot analysis of PURB in extracts of various cell lines. Samples were incubated with PURB Polyclonal antibody (Product # PA5-110245) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 90s.
产品信息
PA5-110245
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 213-312 of human PURB (NP_1500931)
偶联物
形式
Liquid
浓度
0.59 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: GGLYGELPEG TSITVDSKRF FFDVGCNKYG VFLRVSEVKP SYRNAITVPF KAWGKFGGAF CRYADEMKEI QERQRDKLYE RRGGGSGGGE ESEGEEVDED
靶标信息
This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: purine-rich element binding protein B; Purine-rich element-binding protein B; Transcriptional regulator protein Pur-beta
基因别名: PURB; PURBETA
UniProt ID: (Human) Q96QR8
Entrez Gene ID: (Human) 5814
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
single-stranded DNA binding
mRNA binding
transcription factor binding
poly(A) RNA binding
SMAD binding
DNA-binding transcription factor
