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Drosophila peroxidasin is an extracellular matrix-associated peroxidase (Horikoshi et al., 1999 [PubMed 10441517]). It is expressed exclusively in hemocytes derived from head mesoderm at a very early stage of differentiation. Peroxidasin exists as a homotrimer with a unique hybrid structure that combines an enzymatically functional peroxidase domain with motifs that are typically found in extracellular matrix-associated proteins. It is a secreted protein that contains a secretory recognition sequence at its N terminus. Peroxidasin catalyzes hydrogen peroxide-driven radioiodination, oxidations, and the formation of dityrosine in vitro. It is also thought to function in extracellular matrix consolidation, phagocytosis, and defense.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: hsPxd01; Melanoma-associated antigen MG50; p53-responsive gene 2 protein; Peroxidasin 1; Peroxidasin homolog; Vascular peroxidase 1
基因别名: COPOA; D2S448; D2S448E; KIAA0230; MG50; PRG2; PXD01; PXDN; PXN; VPO; VPO1
UniProt ID: (Human) Q92626
Entrez Gene ID: (Human) 7837
分子生物学功能: peroxidase