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Invitrogen
PXMP2 Polyclonal Antibody
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产品信息
PA5-75898
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues in Human PXMP2.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
Peroxisomes are subcellular organelles with important functions in lipid metabolism that are found in virtually all eucaryotic cells. The peroxisomal membrane contains a number of integral and peripheral membrane proteins involved in the import of peroxisomal matrix proteins and the transport of metabolites across the membrane. Pxmp2 (Peroxisomal membrane protein 2), also known as PMP22, is a 195 amino acid multi-pass membrane protein that belongs to the peroxisomal membrane protein PXMP2/4 family. The Pxmp2 protein interacts with both Peroxin 19 and Siva proteins. The Peroxin 19 protein binds multiple peroxisomal membrane proteins (PMPs), is predominantly cytoplasmic, and is required for peroxisome membrane synthesis. Pxmp2 is the most abundant peroxisomal membrane protein in higher eukaryotes. Pxmp2's expression is tissue-specific with highest levels of expression in liver, kidney and heart tissue. It has been suggested that Pxmp2 is involved in pore-forming activity and may contribute to the broad permeability of the peroxisomal membrane. Disruption of the mouse Pxmp2 gene leads to partial restriction of peroxisomal membrane permeability to solutes in vitro and in vivo. The Pxmp2 gene is conserved in chimpanzee, dog, cow, mouse, rat, zebrafish, fruit fly and mosquito, and maps to human chromosome 12q24.33.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 22 kDa peroxisomal membrane protein; liver regeneration-related protein LRRG01; Peroxisomal membrane protein 2; peroxisomal membrane protein 2, 22 kDa; peroxisomal membrane protein 2, 22kDa
基因别名: PMP22; PXMP2; T44
UniProt ID: (Human) Q9NR77, (Rat) Q07066
Entrez Gene ID: (Human) 5827, (Rat) 29533
