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Invitrogen
PYGL Polyclonal Antibody
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PYGL Antibody (PA5-100029) in IHC (P)
Immunohistochemistry analysis of PYGL in human normal tissues adjacent to colorectal cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with PYGL polyclonal antibody (Product # PA5-100029) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-100029
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human PYGL(Accession P06737), corresponding to amino acid residues G205-L255.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total PYGL.
靶标信息
This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: glycogen liver; Glycogen phosphorylase, liver form; GPLL; liver glycogen phosphorylase
基因别名: GSD6; Lgp; PYGL
UniProt ID: (Human) P06737, (Mouse) Q9ET01, (Rat) P09811
Entrez Gene ID: (Human) 5836, (Mouse) 110095, (Rat) 64035
purine nucleobase binding
protein binding
ATP binding
glucose binding
drug binding
glycogen phosphorylase activity
AMP binding
vitamin binding
pyridoxal phosphate binding
bile acid binding
protein homodimerization activity
nucleotide binding
catalytic activity
phosphorylase activity
transferase activity
transferase activity, transferring glycosyl groups
carbohydrate binding
glycosyltransferase
transferase
metabolite interconversion enzyme
