Invitrogen

PYGO1 Polyclonal Antibody

Name: PYGO1 Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-47501

查看其他9个PYGO1抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

Immunogen image

Immunogen Image PYGO1 Polyclonal Antibody

产品信息

PA5-47501

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.1 µg/mL

产品规格

种属反应

Mouse

宿主/亚型

Goat / IgG

分类

Polyclonal

类型

Antibody

抗原

E. coli-derived recombinant mouse Pygopus-1 Ser2-Ala417

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

0.2 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS with 5% trehalose

内含物

No Preservative

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

AB_2605587

产品详细信息

Reconstitute at 0.2 mg/mL in sterile PBS.

靶标信息

Pygopus 1 (PYGO1) is a gene located on chromosome 6p21.31, encoding a protein that plays a crucial role in the Wnt signaling pathway, which is fundamental for various developmental processes including cell proliferation, polarity, and fate determination. PYGO1 is a part of the Pygopus family of proteins, characterized by their Plant Homeodomain (PHD) finger domain that facilitates interaction with histones. Within the Wnt signaling pathway, PYGO1 acts as a coactivator by binding to components of the transcription complex, thus aiding in the expression of Wnt target genes. The protein is especially important in embryonic development and is implicated in specific processes such as limb formation and neural development. Dysregulation of PYGO1 and the Wnt pathway is associated with developmental disorders and certain cancers, demonstrating the protein's significance in maintaining cellular homeostasis. Current studies are focusing on the mechanistic aspects of PYGO1's function in transcription regulation and its potential role in therapeutic strategies targeting Wnt signaling-related diseases.

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