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Invitrogen
PYGO2 Polyclonal Antibody
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产品信息
PA5-82841
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: SLSQRFAQPG APFGPSPLQR PGQGLPSLPP NTSPFPGPDP GFPGPGGEDG GKPLNPPAST AFPQEPHSGS PAAAVNGNQP SFPPNSSGRG GGTPDANSLA PPGKAGGGSG PQPPPGLVYP CGA
Highest antigen sequence indentity to the following orthologs: Mouse - 95%, Rat - 95%.
靶标信息
The PYGO2 gene encodes pygopus family PHD finger 2, a key component of the Wnt signaling pathway, which is critical for embryonic development, cell proliferation, and differentiation. PYGO2 operates as a chromatin remodeling factor, interacting with the beta-catenin-LEF/TCF transcriptional complex, facilitating the transcription of Wnt target genes by recruiting chromatin-modifying enzymes. This activity is vital for maintaining the balance between stem cell renewal and differentiation in various tissues, including the brain and the skin. Additionally, PYGO2 plays significant roles in spermatogenesis and hematopoiesis by modulating gene expression necessary for these processes. Dysregulation of PYGO2 expression can lead to developmental abnormalities and is often implicated in cancer progression, indicating its potential as a biomarker for tumorigenic stem cell-like properties and metastatic behavior. Research continues to explore PYGO2's mechanisms and interactions to understand its contributions to development and its implications in disease states, particularly in cancer biology.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: mpygo2; pygopus 2; Pygopus homolog 2
基因别名: 1190004M21Rik; PP7910; PYGO2
UniProt ID: (Human) Q9BRQ0
Entrez Gene ID: (Human) 90780
in utero embryonic development
kidney development
lens development in camera-type eye
spermatid nucleus differentiation
brain development
post-embryonic development
mammary gland development
regulation of mammary gland epithelial cell proliferation
regulation of histone acetylation
positive regulation of chromatin binding
developmental growth
regulation of histone H3-K4 methylation
palate development
canonical Wnt signaling pathway
beta-catenin-TCF complex assembly
