Invitrogen

PYK2 Monoclonal Antibody (5E2D5)

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说明书
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PYK2 Monoclonal Antibody (5E2D5)

产品信息

MA5-15407

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
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免疫组化（石蜡） (IHC (P))

1:200-1:1,000
-

酶联免疫吸附实验 (ELISA)

1:10,000
-
产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Mouse / IgG2a

分类

Monoclonal

类型

Antibody

克隆号

5E2D5

抗原

Purified recombinant fragment of PYK2 (aa815-997) expressed in E. Coli.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

Conc. Not Determined

保存液

ascites

内含物

0.03% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_10984041

产品详细信息

MA5-15407 targets PYK2 in indirect ELISA, IHC and WB applications and shows reactivity with Human samples.

The MA5-15407 immunogen is purified recombinant fragment of PYK2 (aa815-997) expressed in E. Coli.
.

MA5-15407 detects PYK2 which has a predicted molecular weight of approximately 115.8kDa.

靶标信息

PTK2B (FAK2) is a cytoplasmic tyrosine kinase involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. PTK2B regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading, and bone remodeling. FAK2 plays a role in the regulation of the humoral immune response and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. It functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors, cytokine, chemokine, and growth factor receptors, and mediates responses to cellular stress. Aberrant FAK2 expression may play a role in cancer cell proliferation, migration, and invasion in tumor formation and metastasis. Elevated expression has been seen in gliomas, hepatocellular carcinoma, lung cancer, and breast cancer.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: CADTK; CAK-beta; Calcium-dependent tyrosine kinase; Calcium-regulated non-receptor proline-rich tyrosine kinase; Cell adhesion kinase beta; FADK; FADK 2; FAK; FAK1; Focal adhesion kinase 2; FRNK; pp125FAK; Proline-rich tyrosine kinase 2; protein kinase B; Protein-tyrosine kinase 2-beta; PTK2B protein tyrosine kinase 2 beta; RAFTK; Related adhesion focal tyrosine kinase

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基因别名: CADTK; CAKB; FADK2; FAK2; PKB; PTK; PTK2B; PYK2; RAFTK

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UniProt ID: (Human) Q14289

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Entrez Gene ID: (Human) 2185

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功能
calmodulin-dependent protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity signal transducer activity NMDA glutamate receptor activity receptor binding protein binding ATP binding protein complex binding 3-phosphoinositide-dependent protein kinase binding
参与通路
MAPK cascade angiogenesis oocyte maturation response to hypoxia positive regulation of cell-matrix adhesion sprouting angiogenesis adaptive immune response marginal zone B cell differentiation protein complex assembly protein phosphorylation apoptotic process response to stress cellular defense response response to osmotic stress signal transduction cell surface receptor signaling pathway signal complex assembly epidermal growth factor receptor signaling pathway positive regulation of cytosolic calcium ion concentration integrin-mediated signaling pathway positive regulation of cell proliferation negative regulation of cell proliferation regulation of cell shape response to mechanical stimulus response to hormone response to glucose response to lithium ion positive regulation of endothelial cell migration negative regulation of muscle cell apoptotic process regulation of cGMP-mediated signaling regulation of macrophage chemotaxis positive regulation of neuron projection development glial cell proliferation peptidyl-tyrosine phosphorylation regulation of cell adhesion positive regulation of cell growth positive regulation of cell migration negative regulation of bone mineralization regulation of cGMP biosynthetic process positive regulation of actin filament polymerization neuron projection development regulation of inositol trisphosphate biosynthetic process tumor necrosis factor-mediated signaling pathway ionotropic glutamate receptor signaling pathway response to immobilization stress peptidyl-tyrosine autophosphorylation response to cocaine response to drug response to hydrogen peroxide activation of Janus kinase activity negative regulation of apoptotic process stress fiber assembly negative regulation of potassium ion transport positive regulation of JUN kinase activity negative regulation of neuron apoptotic process blood vessel endothelial cell migration positive regulation of phosphatidylinositol 3-kinase activity innate immune response positive regulation of nitric oxide biosynthetic process bone resorption response to ethanol negative regulation of myeloid cell differentiation positive regulation of translation positive regulation of angiogenesis positive regulation of protein kinase activity positive regulation of JNK cascade protein autophosphorylation vascular endothelial growth factor receptor signaling pathway focal adhesion assembly positive regulation of peptidyl-tyrosine phosphorylation regulation of calcium-mediated signaling positive regulation of nitric-oxide synthase activity regulation of release of sequestered calcium ion into cytosol response to cAMP response to calcium ion positive regulation of synaptic transmission, glutamatergic long-term synaptic potentiation long term synaptic depression chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade cellular response to retinoic acid cellular response to fluid shear stress activation of GTPase activity regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process regulation of establishment of cell polarity regulation of actin cytoskeleton reorganization regulation of N-methyl-D-aspartate selective glutamate receptor activity positive regulation of excitatory postsynaptic potential positive regulation of B cell chemotaxis positive regulation of DNA biosynthetic process
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