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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
The protein encoded by this gene is highly expressed in late-pregnancy serum and is similar in structure to alpha-2-macroglobulin. The encoded protein, which acts as a homotetramer, inhibits the activity of all four classes of proteinases. This protein contains cleavage sites for several proteinases. Upon binding of a proteinase, the conformation of this protein changes to trap the proteinase, limiting its activity. This protein appears to be elevated in the sera of presymptomatic Alzheimer's disease patients.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: A1m {ECO:0000312|EMBL:AAA40723.1}; Alpha-1-M; Alpha-1-macroglobulin; Alpha-1-macroglobulin 165 kDa subunit
基因别名: A1m; Pzp
UniProt ID: (Rat) Q63041
Entrez Gene ID: (Rat) 252922