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Antibodies Inc
Pan-GRK Monoclonal Antibody (N145/20)
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产品信息
75-179
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
N145/20
抗原
Fusion protein amino acids 381-590 (C-terminus) of mouse GRK5 (accession number Q8VEB1) produced recombinantly in E. Coli.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4
内含物
0.065% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Dry ice (international)
产品详细信息
For maximum recovery of product, centrifuge the vial prior to removing the cap.
靶标信息
GRK5 and GRK6 (G protein-coupled receptor kinases 5 and 6) are members of the GRK family of serine/threonine kinases. These kinases play a crucial role in the regulation of G protein-coupled receptors (GPCRs), which are involved in many physiological processes and are targets for a large number of drugs. Dysregulation of GRK5 and GRK6 has been implicated in various diseases, such as heart failure, hypertension, and certain psychiatric disorders. Their role in GPCR regulation makes them potential targets for therapeutic intervention in these conditions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Alpha-CP4; FP2025; G protein-coupled receptor kinase 5; G protein-coupled receptor kinase 6; G protein-coupled receptor kinase GRK5; G protein-coupled receptor kinase GRK6; G-protein coupled receptor kinase 6; Poly(rC)-binding protein 4
基因别名: 1200003L19Rik; AlphaCP-4; GPRK5; GPRK6; GRK5; GRK6; Pcbp4
UniProt ID: (Human) P34947, (Human) P43250, (Mouse) Q8VEB1, (Rat) Q62833, (Mouse) O70293, (Mouse) P57724
Entrez Gene ID: (Human) 2869, (Human) 2870, (Mouse) 14773, (Rat) 59075, (Mouse) 26385, (Rat) 59076, (Mouse) 59092
protein serine/threonine kinase activity
G-protein coupled receptor kinase activity
protein kinase C binding
protein binding
ATP binding
phospholipid binding
beta-adrenergic receptor kinase activity
nucleotide binding
protein kinase activity
lipid binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
nucleic acid binding
DNA binding
RNA binding
poly(A) RNA binding
RNA metabolism protein
non-receptor serine/threonine protein kinase
desensitization of G-protein coupled receptor protein signaling pathway
apoptotic process
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
tachykinin receptor signaling pathway
regulation of G-protein coupled receptor protein signaling pathway
positive regulation of cell proliferation
Wnt signaling pathway
response to drug
negative regulation of apoptotic process
fat cell differentiation
protein autophosphorylation
regulation of cell cycle
protein phosphorylation
negative regulation of anion channel activity
signal transduction
phosphorylation
termination of G-protein coupled receptor signaling pathway
negative regulation of mRNA splicing, via spliceosome
