Antibodies Inc

Pan-KChIP K+ Channel Monoclonal Antibody (K55/82)

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说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
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说明书
实验方案
问题与答案
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Pan-KChIP K+ Channel Monoclonal Antibody (K55/82)

产品信息

75-006

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000
-

免疫组化（冰冻） (IHC (F))

Assay-dependent
-

免疫细胞化学 (ICC/IF)

1:250
-

酶联免疫吸附实验 (ELISA)

Assay-dependent
-

免疫沉淀 (IP)

Assay-dependent
-

染色质免疫沉淀 实验 (ChIP)

Assay-dependent
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Mouse / IgG2a

分类

Monoclonal

类型

Antibody

克隆号

K55/82

抗原

Fusion protein amino acids 1-216 (full length) of rat KChIP1b (accession number Q8R426) produced recombinantly in E. Coli.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

TBS, pH 7.4

内含物

0.065% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Dry ice (international)

产品详细信息

For maximum recovery of product, centrifuge the vial prior to removing the cap.

靶标信息

Pan-KChIP refers to the collective group of Kv Channel-Interacting Proteins (KChIPs), which are auxiliary subunits that associate with voltage-gated potassium (Kv) channels. These proteins modulate the trafficking, surface expression, and functional properties of Kv channels, thereby influencing neuronal excitability and signaling. Dysregulation of KChIPs has been implicated in various neurological conditions, including epilepsy and ataxia.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: A-type potassium channel modulating protein 3; A-type potassium channel modulatory protein 1; A-type potassium channel modulatory protein 1.2; A-type potassium channel modulatory protein 2; A-type potassium channel modulatory protein 3; A-type potassium channel modulatory protein 4; A-type potassium channel modulatory protein KCNIP1; A-type potassium channel modulatory protein KCNIP2; Calsenilin; calsenilin presenilin-binding protein EF hand transcription factor; calsenilin, presenilin binding protein, EF hand transcription factor; calsenilin, presenilin-binding protein, EF hand transcription fa; calsenilin, presenilin-binding protein, EF hand transcription factor; Calsenilin-like protein; Cardiac voltage-gated potassium channel modulatory subunit; downstream regulatory element-antagonist modulator; DRE-antagonist modulator; DREAM; KChIP1; KChIP2; KChIP3; KChIP4; Kv channel interacting protein 1; Kv channel interacting protein 2; Kv channel interacting protein 3; Kv channel interacting protein 3, calsenilin; Kv channel interacting protein 4; Kv channel-interacting protein 1; Kv channel-interacting protein 2; Kv channel-interacting protein 3; Kv channel-interacting protein 4; potassium channel auxiliary subunit KCHIP2; potassium channel interacting protein 1; potassium channel interacting protein 3; potassium channel interacting protein 4; Potassium channel-interacting protein 1; Potassium channel-interacting protein 2; Potassium channel-interacting protein 4; Vesicle APC-binding protein

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基因别名: 4933407H12Rik; AI413860; AV032399; CALP; Calp250; CSEN; DREAM; KCHIP1; Kchip1.2; KCHIP2; KCHIP3; KCHIP4; KChIP4a; KCNIP1; KCNIP2; KCNIP3; KCNIP4; R74849; rKChIP3; VABP

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UniProt ID: (Human) Q9NZI2, (Human) Q9NS61, (Human) Q9Y2W7, (Human) Q6PIL6, (Mouse) Q9JJ57, (Rat) Q8R426, (Mouse) Q9JJ69, (Rat) Q9JM59, (Mouse) Q9QXT8, (Rat) Q9JM47, (Rat) Q99MG9, (Mouse) Q6PHZ8

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Entrez Gene ID: (Human) 30820, (Human) 30819, (Human) 30818, (Human) 80333, (Mouse) 70357, (Rat) 65023, (Mouse) 80906, (Rat) 56817, (Mouse) 56461, (Rat) 65199, (Rat) 259243, (Mouse) 80334

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功能
voltage-gated ion channel activity potassium channel activity calcium ion binding protein binding potassium channel regulator activity A-type (transient outward) potassium channel activity ion channel binding ER retention sequence binding protein N-terminus binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding transcription corepressor activity metal ion binding protein heterodimerization activity identical protein binding protein C-terminus binding sequence-specific DNA binding calcium-dependent protein binding
参与通路
negative regulation of transcription from RNA polymerase II promoter transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter transport ion transport potassium ion transport intracellular protein transport apoptotic process sensory perception of pain regulation of ion transmembrane transport regulation of neuron apoptotic process negative regulation of transcription, DNA-templated response to pain behavioral response to pain potassium ion transmembrane transport protein localization to plasma membrane regulation of potassium ion transmembrane transport cardiac conduction clustering of voltage-gated potassium channels potassium ion export membrane repolarization protein heterooligomerization detection of calcium ion muscle contraction signal transduction chemical synaptic transmission regulation of heart contraction regulation of cation channel activity positive regulation of action potential biological_process regulation of transcription from RNA polymerase II promoter
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