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Invitrogen

Pan Ras Recombinant Rabbit Monoclonal Antibody (8H2)

查看其他9个Pan Ras抗体

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说明书
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问题与答案
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说明书
Certificates
实验方案
问题与答案
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说明书
Certificates
实验方案
问题与答案
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产品信息

MA573413

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-

免疫组化（石蜡） (IHC (P))

1:100-1:500
-

免疫组化（冰冻） (IHC (F))

1:100-1:500
-

免疫细胞化学 (ICC/IF)

1:50-1:200
-

流式细胞分析 (Flow)

1:50-1:100
-

免疫沉淀 (IP)

1:20-1:50
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

8H2

抗原

KLH conjugated synthetic peptide derived from human Ras.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.125 mg/mL

规格

12.5 µg

纯化类型

Protein A

保存液

TBS, pH 7.4, with 50% glycerol, 1% BSA

内含物

0.02% ProClin 300

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: c-H-ras; c-Ha-ras p21 protein; c-Ha-ras transgene; c-K-ras; c-K-ras2 protein; c-Ki-ras; c-Kirsten-ras proto-oncogene; cellular c-Ki-ras2; GTPase HRas; GTPase Hras1; GTPase KRas; GTPase NRas; H-ras 1 protein; H-Ras-1; Ha-Ras; Harvey ras1 protein; Harvey rat sarcoma viral (v-Ha-ras) oncogene homolog; Harvey rat sarcoma virus oncogene 1; K RAS; K-Ras 2; Ki-Ras; Kirsten rat sarcoma oncogene 2, expressed; Kirsten rat sarcoma viral oncogene homologue 2 (active); Neuroblastoma RAS; neuroblastoma RAS viral (v-ras) oncogene homolog; p21 protein; p21ras; RASK; RASN; Transforming protein N-Ras; Transforming protein p21; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog

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基因别名: AI929937; AV095280; c-H-ras; c-Ha-ras; c-Ki-ras; c-rasHa; H-ras; Ha-ras; Harvey-ras; HRAS; Hras-1; HRAS1; K-ras; Ki-ras; KRAS; Kras-2; KRAS2; N-ras; NRAS; p21; p21B; ras; RASK2

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UniProt ID: (Mouse) Q61411, (Rat) P20171, (Rat) P08644, (Mouse) P32883, (Rat) Q04970

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Entrez Gene ID: (Mouse) 15461, (Rat) 293621, (Rat) 24525, (Mouse) 16653, (Mouse) 18176, (Rat) 24605

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功能
nucleotide binding protein binding GTP binding protein C-terminus binding GTPase activity GMP binding GDP binding LRR domain binding protein complex binding molecular_function small GTPase
参与通路
positive regulation of protein phosphorylation endocytosis apoptotic process cell cycle arrest mitotic cell cycle checkpoint signal transduction small GTPase mediated signal transduction Ras protein signal transduction cell aging cell proliferation positive regulation of cell proliferation negative regulation of cell proliferation positive regulation of gene expression negative regulation of gene expression positive regulation of cell migration negative regulation of GTPase activity positive regulation of MAP kinase activity positive regulation of MAPK cascade negative regulation of neuron apoptotic process positive regulation of GTPase activity positive regulation of DNA replication positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade positive regulation of Ras protein signal transduction regulation of long-term neuronal synaptic plasticity positive regulation of epithelial cell proliferation protein heterooligomerization positive regulation of ERK1 and ERK2 cascade positive regulation of wound healing cellular senescence intrinsic apoptotic signaling pathway positive regulation of ruffle assembly positive regulation of actin cytoskeleton reorganization positive regulation of miRNA metabolic process visual learning actin cytoskeleton organization regulation of synaptic transmission, GABAergic positive regulation of Rac protein signal transduction social behavior negative regulation of cell differentiation striated muscle cell differentiation epithelial tube branching involved in lung morphogenesis cytokine-mediated signaling pathway homeostasis of number of cells within a tissue positive regulation of nitric-oxide synthase activity positive regulation of NF-kappaB transcription factor activity response to glucocorticoid response to mineralocorticoid regulation of protein phosphorylation regulation of gene expression positive regulation of fibroblast proliferation negative regulation of skeletal muscle tissue development regulation of cell cycle establishment of protein localization to Golgi biological_process
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