Search
Invitrogen
Pan SHANK Monoclonal Antibody (N23b/49), FITC
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
图: 1 / 3
Pan SHANK Antibody (MA5-45439) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis using human neuroblastoma cells. Fixation involved 4% Formaldehyde for 15 min at RT. Samples were incubated with SHANK (pan) monoclonal antibody (Product # MA5-45439) at 1:100 for 60 min at RT, followed by Goat Anti-Mouse ATTO 488 at 1:200 for 60 min at RT. Counterstain used was Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1,000, 1:5,000 ... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-45439
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
N23b/49
抗原
Fusion protein amino acids 84-309 of rat Shank2
偶联物
FITC
FITC
FITC
激发/发射光谱
498/517 nm
查看光谱
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein G
保存液
9.1mM sodium bicarbonate/PBS, pH 7.4, with 640.91mM DMSO, 136.36mM ethanolamine
内含物
no preservative
保存条件
4°C, store in dark
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
1 µg/mL of MA5-45439 was sufficient for detection of Shank1-4 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.|Detects approximately 160kDa. Recognizes Shank1, 2 and 3.
靶标信息
Shank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins. Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Studies suggest that Shank2 is expressed in the neurons of the developing retina, and could play a role in the neuronal differentiation of the developing retina. Other recent studies suggest that the disruption of glutamate receptors at the Shank postsynaptic platform could contribute to the destruction of the postsynaptic density, which underlies the synaptic dysfunction and loss in Alzheimer's disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: brain specific protein; brain-specific protein; cortactin SH3 domain-binding protein; cortactin-binding protein 1; CortBP1; GKAP/SAPAP interacting protein; GKAP/SAPAP-interacting protein; multidomain postsynaptic density protein; PDZ-based scaffold protein; ProSAP1 protein; postsynaptic density protein; postsynaptic scaffold protein; proline rich synapse associated protein 2; proline-rich synapse associated protein 1; proline-rich synapse-associated protein 1; proline-rich synapse-associated protein 2; SAPAP-interacting protein synamon; scaffolding protein; SH3 and multiple ankyrin repeat domains protein 2-like; SH3/ankyrin domain gene 1; SH3/ankyrin domain gene 2; SH3/ankyrin domain gene 3; shank postsynaptic density protein; Shank postsynaptic density protein 3a; Shank2; shank3 postsynaptic density protein; somatostatin receptor-interacting protein; SPANK-1; SPANK-2; proSAP2; proline-rich synapse-associated protein 2; SSTR-interacting protein; synamon; unnamed protein product
基因别名: AUTS17; CORTBP1; CTTNBP1; DEL22q13.3; mKIAA1022; ProSAP1; PROSAP2; PSAP2; SCZD15; SHANK; Shank1a; Shank2E; SPANK-1; SPANK-2; SPANK-3; Spank1; SSTRIP; synamon
UniProt ID: (Human) Q9Y566, (Human) Q9UPX8, (Human) Q9BYB0, (Rat) Q9WV48, (Mouse) D3YZU1, (Mouse) Q80Z38, (Rat) Q9QX74, (Rat) Q9JLU4, (Mouse) Q4ACU6
Entrez Gene ID: (Human) 50944, (Human) 22941, (Human) 85358, (Rat) 78957, (Mouse) 243961, (Mouse) 210274, (Rat) 171093, (Rat) 59312, (Mouse) 58234
G-protein coupled receptor binding
protein binding
SH3 domain binding
receptor signaling complex scaffold activity
GKAP/Homer scaffold activity
somatostatin receptor binding
ionotropic glutamate receptor binding
identical protein binding
macromolecular complex binding
ankyrin repeat binding
scaffold protein binding
structural constituent of postsynaptic density
zinc ion binding
receptor binding
long-term memory
associative learning
adult behavior
negative regulation of actin filament bundle assembly
social behavior
protein localization to synapse
olfactory behavior
habituation
modulation of synaptic transmission
synapse organization
neuromuscular process controlling balance
determination of affect
righting reflex
synapse maturation
dendritic spine morphogenesis
positive regulation of dendritic spine development
protein-containing complex assembly
vocalization behavior
AMPA selective glutamate receptor signaling pathway
maintenance of postsynaptic density structure
positive regulation of excitatory postsynaptic potential
synapse assembly
learning
memory
positive regulation of cell proliferation
adult locomotory behavior
response to xenobiotic stimulus
negative regulation of hippo signaling
exploration behavior
positive regulation of synaptic transmission, glutamatergic
long-term synaptic potentiation
long term synaptic depression
regulation of postsynapse organization
MAPK cascade
embryonic epithelial tube formation
learning or memory
locomotory behavior
gene expression
glial cell proliferation
striatal medium spiny neuron differentiation
locomotory exploration behavior
locomotion
vocal learning
negative regulation of cell volume
regulation of synaptic plasticity
positive regulation of long-term neuronal synaptic plasticity
brain morphogenesis
sensory perception of touch
positive regulation of synapse structural plasticity
regulation of dendritic spine morphogenesis
neural precursor cell proliferation
postsynaptic density assembly
AMPA glutamate receptor clustering
NMDA glutamate receptor clustering
guanylate kinase-associated protein clustering
response to interleukin-17
regulation of long-term synaptic potentiation
positive regulation of long-term synaptic potentiation
positive regulation of glutamate receptor signaling pathway
regulation of long term synaptic depression
regulation of AMPA glutamate receptor clustering
regulation of grooming behavior
regulation of behavioral fear response
cognition
response to nutrient
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
