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Positive Samples: PC-3, A-431, Mouse brain, Rat brain
Immunogen sequence: RPANPDEIGN FIDENLKAAD TDPTAPPYDS LLVFDYEGSG SEAASLSSLN SSESDKDQDY DYLNEWGNRF KKLADMYGGG EDD
Pan Cadherin including CDH1, CDH2, CDH3, CDH4 protein belong to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. N-cadherin's function is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of beta-catenin.This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product.
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仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: ARC-1; cadherin 1, E-cadherin (epithelial); cadherin 1, type 1; cadherin 1, type 1, E-cadherin (epithelial); cadherin 2 type 1 N-cadherin (neuronal); cadherin 2, type 1, N-cadherin (neuronal); cadherin 3, type 1, P-cadherin (placental); cadherin 4 type 1 R-cadherin (retinal); cadherin 4, type 1, preproprotein; cadherin 4, type 1, R-cadherin (retinal); cadherin e; Cadherin-1; Cadherin-2; Cadherin-3; Cadherin-4; cadherin-E; calcium-dependent adhesion protein, epithelial; calcium-dependent adhesion protein, neuronal; calcium-dependent adhesion protein, placental; CAM 120/80; CD324; CD325; CDw325; CDw325 antigen; cell-CAM 120/80; E-Cadherin; E-cadherin 1; Epithelial cadherin; N-cadherin; N-cadherin 1; Neural cadherin; P-cadherin; Pan Cadherin; Placental cadherin; Placental-cadherin; R-CAD; R-cadherin; retina cadherin; Retinal cadherin; RPE-specific cadherin; Uvomorulin
基因别名: AA960649; AI385538; Arc-1; AW120700; CAD4; Cadp; CD324; CD325; CDH1; CDH2; CDH3; CDH4; Cdh4l; CDHE; CDHN; CDHP; CDw325; E-cad; ECAD; HJMD; L-CAM; LCAM; N-cadherin; NCAD; P-cadherin; PCAD; R-CAD; R-Cadh; R-cadherin; RCAD; Um; UVO
UniProt ID: (Human) P12830, (Human) P19022, (Human) P22223, (Human) P55283, (Mouse) P09803, (Rat) Q9R0T4, (Mouse) P15116, (Rat) Q9Z1Y3, (Mouse) P10287, (Mouse) P39038
Entrez Gene ID: (Human) 999, (Human) 1000, (Human) 1001, (Human) 1002, (Mouse) 12550, (Rat) 83502, (Mouse) 12558, (Rat) 83501, (Rat) 116777, (Mouse) 12560, (Mouse) 12561, (Rat) 114588
分子生物学功能: cadherin