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Invitrogen
Pan-cadherin Recombinant Rabbit Monoclonal Antibody (6N5P8)
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Pan-cadherin Antibody (MA5-35605) in IHC (P)
Immunohistochemistry analysis of Pan-cadherin in paraffin-embedded human thyroid cancer. Samples were incubated with Pan-cadherin Monoclonal antibody (Product # MA5-35605) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-35605
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
6N5P8
抗原
Synthetic peptide
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.33 mg/mL
规格
33 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: IRRMDERPIH AEPQYPVRSA APHPGDIGDF INEGLKAADN DPTAPPYDSL LVFDYEGSGS TAGSLSSLNS SSSGGEQDYD YLNDWGPRFK KLADMYGGGD D
靶标信息
Pan Cadherin including CDH1, CDH2, CDH3, CDH4 protein belong to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. N-cadherin's function is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of beta-catenin.This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ARC-1; cadherin e; Cadherin-1; Cadherin-2; Cadherin-3; Cadherin-4; cadherin-E; Cadherin-N; CAM 120/80; CD324; CD325; CDw325; CDw325 antigen; E-cadherin; Epithelial cadherin; N-cadherin; Neural cadherin; Neural-cadherin; P-cadherin; Pan Cadherin; Placental cadherin; Placental-cadherin; R-CAD; retina cadherin; Retinal cadherin; RPE-specific cadherin; Uvomorulin
基因别名: AA960649; AI385538; AW120700; Cadp; CDH1; CDH2; CDH3; CDH4; CDHE; CDHN; CDHP; E-cad; Ecad; L-CAM; N-cadherin; NCAD; P-cadherin; Pcad; R-Cadh; R-cadherin; Rcad; Um; UVO
UniProt ID: (Mouse) P09803, (Mouse) P15116, (Mouse) P10287, (Mouse) P39038
Entrez Gene ID: (Mouse) 12550, (Mouse) 12558, (Mouse) 12560, (Mouse) 12561
glycoprotein binding
calcium ion binding
protein binding
beta-catenin binding
protein phosphatase binding
protein domain specific binding
ankyrin binding
GTPase activating protein binding
gamma-catenin binding
metal ion binding
cell adhesion molecule binding
enzyme binding
protein kinase binding
protein complex binding
alpha-catenin binding
nitric-oxide synthase binding
cadherin
in utero embryonic development
trophectodermal cell differentiation
epithelial cell morphogenesis
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
synapse assembly
sensory perception of sound
single organismal cell-cell adhesion
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
protein metabolic process
negative regulation of cell-cell adhesion
regulation of protein localization
regulation of water loss via skin
adherens junction organization
positive regulation of transcription factor import into nucleus
regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of transcription, DNA-templated
regulation of epithelial cell proliferation
negative regulation of epithelial cell proliferation
protein homooligomerization
intestinal epithelial cell development
salivary gland cavitation
regulation of branching involved in salivary gland morphogenesis
bicellular tight junction assembly
cellular response to amino acid stimulus
cellular response to lithium ion
cellular response to indole-3-methanol
protein localization to plasma membrane
establishment of protein localization to plasma membrane
negative regulation of canonical Wnt signaling pathway
cochlea development
regulation of protein localization to cell surface
regulation of neuron migration
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
regulation of signal transduction
glial cell differentiation
cell migration
regulation of myelination
regulation of Rho protein signal transduction
positive regulation of MAPK cascade
cell-cell adhesion mediated by cadherin
blood vessel morphogenesis
regulation of axonogenesis
striated muscle cell differentiation
protein heterooligomerization
neuroligin clustering involved in postsynaptic membrane assembly
neuronal stem cell population maintenance
regulation of postsynaptic density protein 95 clustering
positive regulation of synaptic vesicle clustering
retina homeostasis
positive regulation of gene expression
positive regulation of keratinocyte proliferation
hair cycle process
keratinization
positive regulation of monophenol monooxygenase activity
negative regulation of transforming growth factor beta2 production
positive regulation of insulin-like growth factor receptor signaling pathway
positive regulation of melanin biosynthetic process
negative regulation of catagen
canonical Wnt signaling pathway
regulation of hair cycle by canonical Wnt signaling pathway
positive regulation of melanosome transport
axon guidance
positive regulation of axon extension
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