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Invitrogen
Paromomycin Recombinant Mouse Monoclonal Antibody (2D3)
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Paromomycin Antibody (MA566380) in SDS-PAGE
SDS-PAGE characterization of Paromomycin under reducing conditions. Lane M: Protein marker (kDa); Lane PAM: Purified Paromomycin Recombinant Monoclonal (Product # MA566380). Paromomycin showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-399.
产品信息
MA566380
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
2D3
抗原
Conjugate of PAM hapten and KLH.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
5.1 mg/mL
规格
200 µg
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Paromomycin is an aminoglycoside antibiotic derived from Streptomyces rimosus, exhibiting broad-spectrum activity against various infections such as amoebiasis, cryptosporidiosis, giardiasis, and numerous gram-negative and gram-positive bacteria. Its structure is characterized by a complex arrangement of sugar moieties, which contribute to its binding affinity and mechanism of action, primarily targeting the bacterial ribosome to inhibit protein synthesis. Paromomycin's gene location and modifications have been explored to enhance its efficacy and overcome resistance, with targeted chemical syntheses revealing efficient modifications within the neomycin family. These modifications aim to convert neomycin and its derivatives into more potent forms, addressing the growing concern of antibiotic resistance. Paromomycin is also investigated as a selection agent in transgenic plant studies, demonstrating its versatility beyond clinical applications.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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