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Invitrogen
Penicillinase Polyclonal Antibody, Biotin
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产品信息
PA1-27255
产品规格
种属反应
Bacteria
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Penicillinase purified from Enterobacter cloacae.
偶联物
形式
Liquid
浓度
10 mg/mL
纯化类型
IgG fraction
保存液
PBS, pH 7.2, with 1% BSA
内含物
0.01% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
PA1-27255 detects Penicillinase from Enterobacter cloacae samples.
靶标信息
Penicillinase, also known as beta-lactamase, is an enzyme produced by certain bacteria that confers resistance to penicillin and other beta-lactam antibiotics. This enzyme works by hydrolyzing the beta-lactam ring of penicillin, rendering the antibiotic ineffective in inhibiting bacterial cell wall synthesis. Penicillinase is encoded by various bacterial genes, commonly found in plasmids or chromosomes, which can be transferred between bacteria, leading to the spread of antibiotic resistance. This enzyme is a significant concern in treating bacterial infections, as it diminishes the efficacy of beta-lactam antibiotics, which are widely used in clinical settings. The presence of penicillinase-producing bacteria necessitates the use of alternative antibiotics or combination therapies that include beta-lactamase inhibitors, such as clavulanic acid, to restore the antibiotic's effectiveness. Monitoring and studying penicillinase activity are crucial for managing antibiotic resistance and developing new therapeutic strategies to combat resistant bacterial strains.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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