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Invitrogen
Pepsinogen I Recombinant Rabbit Monoclonal Antibody (6L10S1)
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Pepsinogen I Antibody (MA5-58064) in IHC (P)
Immunohistochemistry analysis of Pepsinogen I with paraffin-embedded Mouse stomach tissue. The tissue was incubated with Pepsinogen I Recombinant Monoclonal Antibody (Product # MA5-58064) using a 1:200 dilution (40x lens). High pressure antigen retrieval performed with 0.01M Citrate Buffer (pH 6.0) prior to staining.
产品信息
MA5-58064
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
6L10S1
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-388 of human Pepsinogen I (PG I) (NP_001073276.1).
偶联物
形式
Liquid
浓度
1.01 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.09% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
产品详细信息
Immunogen sequence: MKWLLLLGLV ALSECIMYKV PLIRKKSLRR TLSERGLLKD FLKKHNLNPA RKYFPQWEAP TLVDEQPLEN YLDMEYFGTI GIGTPAQDFT VVFDTGSSNL WVPSVYCSSL ACTNHNRFNP EDSSTYQSTS ETVSITYGTG SMTGILGYDT VQVGGISDTN QIFGLSETEP GSFLYYAPFD GILGLAYPSI SSSGATPVFD NIWNQGLVSQ DLFSVYLSAD DQSGSVVIFG GIDSSYYTGS LNWVPVTVEG YWQITVDSIT MNGEAIACAE GCQAIVDTGT SLLTGPTSPI ANIQSDIGAS ENSDGDMVVS CSAISSLPDI VFTINGVQYP VPPSAYILQS EGSCISGFQG MNLPTESGEL WILGDVFIRQ YFTVFDRANN QVGLAPVA
靶标信息
PGA5: Pepsinogen 5, group I (pepsinogen A). Pepsinogens are the inactive precursors of pepsin, the major acid protease found in the stomach. Pepsin is one of the main proteolytic enzymes secreted by the gastric mucosa. Pepsin consists of a single polypeptide chain and arises from its precursor, pepsinogen, by removal of a 41 amino acid segment from the N-terminus. Pepsinogen is synthesized in the stomach lining, and hydrochloric acid, also produced by the gastric mucosa, is necessary to convert the inactive enzyme and to maintain the optimum acidity (pH 1-3) for pepsin function. Pepsin is particularly effective in cleaving peptide bonds involving aromatic amino acids. Pepsin shows extremely broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent. PGA5 is a member of the subfamily A1 within the pepsin family and is the predominant endopeptidase in the gastric juice of vertebrates. PGA5 is inhibited by ovUS-1, a uterine serpin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Pepsin A-5; Pepsin F; pepsinogen 5, group I; pepsinogen 5, group I (pepsinogen A); pepsinogen A5; pepsinogen F; pepsinogen F protein
基因别名: 1110035E17Rik; Pepf; Pga5
UniProt ID: (Mouse) Q9D106
Entrez Gene ID: (Mouse) 58803, (Rat) 60372
