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Invitrogen
Pertussis toxin subunit 2 (SYN-005-11E6 Biosimilar) Recombinant Human Monoclonal Antibody
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产品信息
MA562758
应用
建议稀释比
已发表文章
产品规格
种属反应
Bacteria
宿主/亚型
Human
/ IgG1, kappa
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Pertussis toxin (PT) is a multi-subunit protein exotoxin produced by Bordetella pertussis, the bacterium responsible for whooping cough. The toxin consists of five subunits (S1 to S5), with subunit 2 (S2) playing a crucial role in the toxin's ability to bind to host cells. Structurally, the S2 subunit, along with S3, forms a part of the B oligomer, which binds to lactosylceramide on the surface of respiratory epithelial cells. Functionally, the S2 subunit, through its interaction with the cellular receptor, enables the A subunit (S1) to be delivered into the host cell. This leads to the ADP-ribosylation of the Gi protein, disrupting cellular signaling and weakening the immune defenses of the host. Thus, the S2 subunit is essential for the attachment and effectiveness of the pertussis toxin in initiating infection.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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