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Invitrogen
Phenacetin Recombinant Mouse Monoclonal Antibody (3G11)
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Phenacetin Antibody (MA566370) in SDS-PAGE
SDS-PAGE characterization of Phenacetin under reducing conditions. Lane M: Protein marker (kDa); Lane PNT: Purified Phenacetin Recombinant Monoclonal (Product # MA566370). Phenacetin showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-638.
产品信息
MA566370
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
3G11
抗原
Conjugate of PNT hapten and KLH.
偶联物
形式
Liquid
浓度
7.2 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Phenacetin is a synthetic compound that was historically used as an analgesic and antipyretic medication, primarily for the relief of mild to moderate pain and fever. Structurally, phenacetin belongs to the class of aniline derivatives, characterized by an ethoxy group attached to the phenyl ring, which contributes to its pharmacological activity. Earlier marketed formulations included those for treating headaches and arthritis symptoms; however, concerns about nephrotoxicity and methemoglobinemia led to its withdrawal from most markets globally. Phenacetin undergoes metabolism predominantly in the liver, where it is transformed into acetaminophen, its active metabolite. Despite its former therapeutic applications, phenacetin is no longer favored due to the discovery of safer alternatives and its association with conditions such as renal papillary necrosis. Research into phenacetin today focuses on understanding its historical use and the implications of its metabolism in drug safety evaluations.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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