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Invitrogen
PhenylethanolaMine A Recombinant Mouse Monoclonal Antibody (2G10)
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PhenylethanolaMine A Antibody (MA566368) in SDS-PAGE
SDS-PAGE characterization of PhenylethanolaMine A under reducing conditions. Lane M: Protein marker (kDa); Lane PEA: Purified PhenylethanolaMine A Recombinant Monoclonal (Product # MA566368). PhenylethanolaMine A showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-260.
产品信息
MA566368
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
2G10
抗原
Conjugate of PEA hapten and KLH.
偶联物
形式
Liquid
浓度
5.1 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Phenylethanolamine A is associated with the enzyme phenylethanolamine N-methyltransferase (PNMT), which plays a crucial role in the biosynthesis of epinephrine by catalyzing the methylation of norepinephrine. PNMT is primarily located in the adrenal medulla and is encoded by a single gene with three exons. Structurally, phenylethanolamine substrates and inhibitors interact with PNMT through conformational and steric aspects, which are important for binding affinity. The enzyme is a potential drug target for controlling hypertension due to its role in epinephrine synthesis, and inhibitors are being designed to selectively target PNMT without affecting other receptors. Phenylethanolamine is also implicated in the regulation of blood pressure, respiration, and conditions such as Alzheimer's disease and PTSD.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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