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Invitrogen
Phl p 1 Chimeric Recombinant Human Monoclonal Antibody (Clone 25)
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Phl p 1 Chimeric Antibody (MA5-51651) in ELISA
ELISA binding curve of Phl p 1 (2 µg/mL) using Phl p 1 Chimeric Recombinant Human Monoclocal Antibody (Product # MA5-51651) at a 3-fold serial dilution from 10,000 to 0.1 ng/mL. For detection, a 1:4,000 dilution of HRP-labelled goat anti-human kappa antibody was used.
产品信息
MA5-51651
产品规格
种属反应
Plant
宿主/亚型
Human
/ IgE, kappa
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
Clone 25
抗原
Recombinant Phl p 1, a grass pollen allergen.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS
内含物
0.02% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody binds to the Timothy grass allergen Phl p 1 and shows cotss reactivity with natural group 1 allergens from a variety of grass species such as oat, sweet vernal grass, Bermuda grass, rye grass, common reed, Kentucky blue grass, rye, wheat and maize (weak).
靶标信息
Phl p 1 binds to specific receptors on the surface of immune cells called TLR4 (Toll-like receptor 4) and MD-2 (myeloid differentiation factor 2). This binding triggers a signaling cascade that leads to the activation of immune cells and the release of inflammatory mediators, which cause the allergic symptoms. The interaction between Phl p 1 and TLR4-MD-2 complex has been studied extensively and is considered a key event in the development of grass pollen allergy. Understanding the molecular mechanisms involved in this interaction is important for developing new therapeutic strategies to treat or prevent allergic reactions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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