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Invitrogen

Phospho-14-3-3 beta/gamma/eta/zeta (Ser58, Ser59, Ser60) Recombinant Rabbit Monoclonal Antibody (10T1L0)

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产品信息

MA569924

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:6,500-1:13,000
-

酶联免疫吸附实验 (ELISA)

1 µg/mL
-
产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

10T1L0

抗原

Synthetic peptide.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.34 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.3., with 50% glycerol

内含物

0.09% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

The 14-3-3 protein family consists of highly conserved regulatory molecules expressed across all eukaryotic cells, serving as a critical hub for diverse cellular processes such as signal transduction, metabolism, apoptosis, and cell cycle control. Structurally, these proteins function by forming dimeric complexes that bind to specific phosphoserine or phosphothreonine motifs on a wide array of target proteins, effectively modulating their stability, activity, or subcellular localization. The family is composed of multiple isoforms that possess both unique and overlapping roles: 14-3-3 Beta and Zeta are heavily involved in cell proliferation and survival, with Zeta specifically aiding in DNA damage responses; 14-3-3 Gamma is essential for neuronal development and stress management; and 14-3-3 Eta acts as a key regulator of the immune response, with its dysregulation serving as a known marker for rheumatoid arthritis. Because these isoforms work in concert to maintain homeostasis, their dysregulation is a significant factor in the development of complex diseases, including various cancers, metabolic conditions, and neurological disorders.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: 14-3-3 alpha; 14-3-3 delta; 14-3-3 eta; 14-3-3 gamma; 14-3-3 protein beta; 14-3-3 protein beta/alpha; 14-3-3 protein eta; 14-3-3 protein gamma; 14-3-3 protein gamma subtype; 14-3-3 protein zeta/delta; 14-3-3 protein/cytosolic phospholipase A2; 14-3-3 zeta; 14-3-3n; 3-monooxgenase/tryptophan 5-monooxgenase activation protein, gamma polypeptide; 3-monooxgenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; AS1; brain-specific tyrosine and tryptophan hydroxylase activator; epididymis luminal protein 4; epididymis secretory protein Li 1; epididymis secretory protein Li 3; epididymis secretory protein Li 93; HS1; KCIP-1; phospholipase A2; Protein 1054; Protein AS1; Protein kinase C inhibitor protein 1; protein kinase C inhibitor protein-1; protein phosphatase 1, regulatory subunit 170; SEZ-2; signal transduction phosphoprotein; similar to Homo sapiens DNA for 14-3-3 protein eta chain, exon 2 with GenBank Accession Number D78577.1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, delta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, beta polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide; unnamed protein product; YWHAG; YWHAH

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基因别名: 1110013I11Rik; 1300003C17Rik; 14-3-3-zeta; 14-3-3GAMMA; 14-3-3zeta; AI596267; AL022924; AU020854; D7Bwg1348e; DEE56; EIEE56; GW128; HEL-S-1; HEL-S-3; HEL-S-93; HEL4; HS1; KCIP-1; POPCHAS; PPP1R170; YWHA1; YWHAA; YWHAB; YWHAD; YWHAG; YWHAH; YWHAZ

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UniProt ID: (Human) P31946, (Human) P61981, (Human) Q04917, (Human) P63104, (Mouse) Q9CQV8, (Mouse) P61982, (Mouse) P68510, (Mouse) P63101

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Entrez Gene ID: (Human) 7529, (Human) 7532, (Human) 7533, (Human) 7534, (Mouse) 54401, (Mouse) 22628, (Mouse) 22629, (Mouse) 22631

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功能
protein kinase inhibitor activity protein phosphatase inhibitor activity protein binding enzyme binding protein domain specific binding identical protein binding histone deacetylase binding macromolecular complex binding cadherin binding phosphoserine binding phosphoprotein binding protein sequestering activity RNA binding protein kinase C binding insulin-like growth factor receptor binding protein kinase C inhibitor activity receptor tyrosine kinase binding phosphorylation-dependent protein binding actin binding sodium channel regulator activity glucocorticoid receptor binding ion channel binding protein heterodimerization activity protein kinase binding protein phosphatase binding ubiquitin protein ligase binding DNA-binding transcription factor binding transcription corepressor activity protein C-terminus binding protein complex binding poly(A) RNA binding transcription factor binding scaffold/adaptor protein
参与通路
protein targeting signal transduction protein localization negative regulation of protein import into nucleus negative regulation of G-protein coupled receptor protein signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter cytoplasmic translation negative regulation of T cell mediated immune response to tumor cell positive regulation of T cell mediated immune response to tumor cell negative regulation of protein kinase activity regulation of signal transduction positive regulation of cell-cell adhesion SCF-dependent proteasomal ubiquitin-dependent protein catabolic process cellular response to nutrient levels cellular response to insulin stimulus regulation of protein localization cellular response to amino acid starvation TORC1 signaling cellular response to glucose starvation proteasome-mediated ubiquitin-dependent protein catabolic process regulation of neuron differentiation negative regulation of translational initiation positive regulation of translational initiation regulation of synaptic plasticity protein stabilization negative regulation of T cell activation positive regulation of T cell activation protein localization to lysosome protein K6-linked ubiquitination negative regulation of TORC1 signaling positive regulation of TORC1 signaling regulation of sodium ion transport glucocorticoid catabolic process intracellular protein transport substantia nigra development glucocorticoid receptor signaling pathway positive regulation of transcription, DNA-templated negative regulation of dendrite morphogenesis membrane depolarization during action potential presynaptic modulation of chemical synaptic transmission negative regulation of transcription from RNA polymerase II promoter angiogenesis respiratory system process protein phosphorylation lysosome organization synaptic target recognition lung development regulation of protein stability tube formation negative regulation of apoptotic process regulation of programmed cell death negative regulation of innate immune response establishment of Golgi localization ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade regulation of synapse maturation Golgi reassembly antibacterial innate immune response negative regulation of protein localization to nucleus regulation of lysosome organization negative regulation of protein dephosphorylation positive regulation of catalytic activity cytoplasmic sequestering of protein protein heterooligomerization cytoskeleton organization regulation of mitotic nuclear division regulation of sodium ion transmembrane transporter activity histamine secretion by mast cell protein targeting to mitochondrion regulation of cell death response to drug
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