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Invitrogen
Phospho-Afadin (Ser1799) Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-104569
产品规格
种属反应
Human,
Non-human primate
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human AFDN(Accession P55196), corresponding to amino acid residues around phosphorylated Ser1799.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of Afadin only when phosphorylated at Ser1799.
靶标信息
AFDN belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ALL-1 fusion partner from chromosome 6; ALL1-fused gene from chromosome 6 protein; FLJ34371; fusion gene; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4; myeloid/lymphoid or mixed-lineage leukemia; translocated to, 4; protein AF-6; RP3-431P23.3; RP3-470B24.4
基因别名: AF6; l-afadin; MLL-AF6; MLLT4
UniProt ID: (Human) P55196
Entrez Gene ID: (Human) 4301
cell adhesion
signal transduction
cell-cell signaling
positive regulation of gene expression
positive regulation of cell-cell adhesion
cell differentiation
negative regulation of cell migration
cell junction organization
adherens junction maintenance
cell-cell adhesion mediated by cadherin
pore complex assembly
establishment of protein localization to plasma membrane
bicellular tight junction assembly
establishment of endothelial intestinal barrier
positive regulation of cell-cell adhesion mediated by cadherin
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