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Phospho-Aurora A/B/C (Thr288, Thr232, Thr198) Recombinant Rabbit Monoclonal Antibody (AuroraABC-CC12)

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Phospho-Aurora A/B/C (Thr288, Thr232, Thr198) Recombinant Rabbit Monoclonal Antibody (AuroraABC-CC12)

产品信息

MA5-37152

应用
建议稀释比
已发表文章

流式细胞分析 (Flow)

1-1,000 ng/mL
-
产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG, kappa

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

AuroraABC-CC12

抗原

A synthetic phospho-peptide corresponding to residues surrounding human Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198).
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Protein A/G

保存液

PBS with 50% glycerol, 0.10% BSA

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2897086

靶标信息

Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPT1, VIM/vimentin, GSG2/Haspin, and histone H3. A positive feedback loop involving GSG2 and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively). A positive feedback between GSG2 and AURKB contributes to CPC localization. AURKB is also required for kinetochore localization of BUB1 and SGOL1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activity. Key regulator of active promoters in resting B- and T-lymphocytes.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: AIM-1; ARK-1; ARK-2; ARK-3; Aurora 1; Aurora 2; Aurora 3; Aurora kinase A; Aurora kinase B; aurora kinase B-Sv1; aurora kinase B-Sv2; Aurora kinase C; Aurora- and IPL1-like midbody-associated protein 1; aurora-1; aurora-B; aurora-related kinase 2; aurora-related kinase 3; aurora/IPL1-like kinase; Aurora/IPL1-related kinase 1; Aurora/IPL1-related kinase 2; Aurora/IPL1-related kinase 3; Aurora/IPL1/Eg2 protein 2; Breast tumor-amplified kinase; epididymis secretory protein Li 90; Ipl1- and aurora-related kinase 1; protein phosphatase 1, regulatory subunit 47; protein phosphatase 1, regulatory subunit 48; serine/threonine kinase 12; serine/threonine kinase 13 (aurora/IPL1-like); serine/threonine protein kinase 15; Serine/threonine-protein kinase 12; Serine/threonine-protein kinase 13; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 5; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase aurora-A; Serine/threonine-protein kinase aurora-B; Serine/threonine-protein kinase aurora-C; Serine/threonine-protein kinase Ayk1; STK-1

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基因别名: AIE2; AIK; AIK2; AIK3; AIM-1; AIM1; AIRK1; AIRK2; AIRK3; ARK1; ARK2; ARK3; AURA; AurB; AurC; AURKA; AURKB; aurkb-sv1; aurkb-sv2; AURKC; aurora-C; AYK1; BTAK; HEL-S-90; IAK1; IPL1; PPP1R47; PPP1R48; SPGF5; STK1; STK12; STK13; STK15; STK5; STK6; STK7

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UniProt ID: (Human) O14965, (Human) Q96DV5, (Human) Q9UQB9

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Entrez Gene ID: (Human) 6790, (Human) 9212, (Human) 6795

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功能
protein kinase activity protein serine/threonine kinase activity protein serine/threonine/tyrosine kinase activity protein binding ATP binding protein kinase binding ubiquitin protein ligase binding histone serine kinase activity metal ion binding non-receptor serine/threonine protein kinase
参与通路
G2/M transition of mitotic cell cycle meiotic spindle organization protein phosphorylation DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest spindle organization mitotic spindle organization spindle assembly involved in female meiosis I mitotic nuclear division mitotic centrosome separation anterior/posterior axis specification anaphase-promoting complex-dependent catabolic process regulation of protein stability negative regulation of protein binding response to estradiol positive regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of cytokinesis histone-serine phosphorylation protein ubiquitination involved in ubiquitin-dependent protein catabolic process negative regulation of apoptotic process positive regulation of mitotic nuclear division regulation of centrosome cycle protein autophosphorylation cell division centrosome localization protein localization to centrosome positive regulation of oocyte maturation regulation of signal transduction by p53 class mediator neuron projection extension negative regulation of transcription from RNA polymerase II promoter negative regulation of B cell apoptotic process sister chromatid cohesion aging cell proliferation attachment of spindle microtubules to kinetochore abscission histone modification protein sumoylation spindle checkpoint positive regulation of telomere maintenance via telomerase negative regulation of cytokinesis positive regulation of cytokinesis protein localization to kinetochore cellular response to UV cleavage furrow formation histone H3-S28 phosphorylation mitotic spindle midzone assembly positive regulation of telomerase activity regulation of chromosome segregation positive regulation of telomere capping cytokinesis spermatogenesis oocyte development meiotic cell cycle
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