Invitrogen

Phospho-BAD (Ser112) Recombinant Rabbit Monoclonal Antibody (BADS112-B9)

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说明书
实验方案
问题与答案
技术支持
Phospho-BAD (Ser112) Recombinant Rabbit Monoclonal Antibody (BADS112-B9)

产品信息

MA5-37058

应用
建议稀释比
已发表文章

流式细胞分析 (Flow)

1-1,000 ng/mL
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

BADS112-B9

抗原

A synthetic phospho-peptide corresponding to residues surrounding Ser112 of human phospho BAD.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Protein A/G

保存液

PBS, pH 7.4, with 0.1% BSA, 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2896993

产品详细信息

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

靶标信息

The protein encoded by BAD is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: BAD; bcl-2 associated death agonist; Bcl-2-binding component 6; Bcl-2-like protein 8; BCL-X/BCL-2 binding protein; Bcl-xL/Bcl-2-associated death promoter; Bcl2 antagonist of cell death; Bcl2-antagonist of cell death; BCL2-antagonist of cell death protein; BCL2-associated agonist of cell death; bcl2-associated death promoter; BCL2-binding component 6; BCL2-binding protein; Bcl2-L-8; OTTMUSP00000017561; OTTMUSP00000022400

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基因别名: AI325008; BAD; BBC2; BBC6; BCL2L8

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UniProt ID: (Human) Q92934, (Mouse) Q61337, (Rat) O35147

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Entrez Gene ID: (Human) 572, (Mouse) 12015, (Rat) 64639

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功能
protein binding phospholipid binding lipid binding cysteine-type endopeptidase activator activity involved in apoptotic process protein kinase binding protein phosphatase 2B binding protein kinase B binding protein heterodimerization activity 14-3-3 protein binding protein phosphatase binding
参与通路
release of cytochrome c from mitochondria glucose catabolic process apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process cell proliferation extrinsic apoptotic signaling pathway via death domain receptors intrinsic apoptotic signaling pathway in response to DNA damage positive regulation of mitochondrial membrane potential suppression by virus of host apoptotic process cytokine-mediated signaling pathway positive regulation of insulin secretion positive regulation of glucokinase activity positive regulation of insulin secretion involved in cellular response to glucose stimulus glucose homeostasis regulation of apoptotic process positive regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of cysteine-type endopeptidase activity involved in apoptotic process type B pancreatic cell proliferation positive regulation of B cell differentiation positive regulation of T cell differentiation positive regulation of proteolysis negative regulation of cytolysis ADP metabolic process ATP metabolic process regulation of mitochondrial membrane permeability pore complex assembly positive regulation of epithelial cell proliferation positive regulation of apoptotic process by virus cellular process regulating host cell cycle in response to virus cellular response to organic substance cellular response to nicotine positive regulation of release of cytochrome c from mitochondria apoptotic signaling pathway extrinsic apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand intrinsic apoptotic signaling pathway activation of cysteine-type endopeptidase activity positive regulation of neuron death positive regulation of type B pancreatic cell development response to hypoxia response to hormone response to glucose response to organic substance response to organic cyclic compound response to estradiol response to progesterone response to testosterone response to oleic acid response to drug response to hydrogen peroxide response to amino acid response to ethanol response to glucocorticoid response to calcium ion cellular response to chromate cellular response to mechanical stimulus cellular response to lipid cellular response to hypoxia protein insertion into mitochondrial membrane involved in apoptotic signaling pathway spermatogenesis positive regulation of autophagy cerebral cortex development positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway positive regulation of intrinsic apoptotic signaling pathway
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