Invitrogen

Phospho-Bcl-3 (Ser41) Polyclonal Antibody

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说明书
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说明书
实验方案
问题与答案
技术支持
Phospho-Bcl-3 (Ser41) Polyclonal Antibody

产品信息

PA5-105525

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-

免疫组化（石蜡） (IHC (P))

1:50-1:200
-
产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human BCL3(Accession P20749), corresponding to amino acid residues around phosphorylated Ser41.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

sequential chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2816953

产品详细信息

Antibody detects endogenous levels of BCL-3 only when phosphorylated at Ser41.

靶标信息

B cell Lymphoma 3 is a member of the IkB subfamily of inhibitors. This subfamily is part of the NF-kB transcription factor protein family and it is suggested that a balance in the concentration of various NF-kB family members regulates apoptosis and survival of activated T cells. Bcl-3 has been shown to have versatile functions such as cytoplasmic activation of p50 homodimers, translocation to the nucleus, and modulation of the transcriptional machinery in the nucleus. Bcl-3 activity often relies on several nuclear interacting proteins such as Tip60, Jab1, Bard1, and Pirin.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: B-cell CLL/lymphoma 3; B-cell leukemia/lymphoma 3; B-cell lymphoma 3 protein; B-cell lymphoma 3 protein homolog; B-cell lymphoma 3-encoded protein; BCL-3; Bcl-3 protein; chronic lymphatic leukemia protein; Proto-oncogene BCL3

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基因别名: AI528691; Bcl-3; BCL3; BCL4; D19S37

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UniProt ID: (Human) P20749, (Mouse) Q9Z2F6

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Entrez Gene ID: (Human) 602, (Mouse) 12051

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功能
DNA binding transcription factor activity, sequence-specific DNA binding protein binding transcription factor binding protein binding, bridging membrane traffic protein
参与通路
protein import into nucleus, translocation follicular dendritic cell differentiation marginal zone B cell differentiation humoral immune response mediated by circulating immunoglobulin germinal center formation transcription, DNA-templated cellular response to DNA damage stimulus I-kappaB kinase/NF-kappaB signaling response to virus response to UV-C antimicrobial humoral response extracellular matrix organization DNA damage response, signal transduction by p53 class mediator positive regulation of interferon-gamma production T-helper 1 type immune response regulation of NF-kappaB import into nucleus negative regulation of tumor necrosis factor biosynthetic process defense response to bacterium intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator defense response to protozoan regulation of apoptotic process negative regulation of apoptotic process T-helper 2 cell differentiation positive regulation of interleukin-10 biosynthetic process negative regulation of interleukin-8 biosynthetic process positive regulation of translation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter spleen development regulation of DNA binding maintenance of protein location in nucleus regulation of transcription, DNA-templated
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