Invitrogen

Phospho-C/EBP alpha (Ser21) Polyclonal Antibody

查看其他19个C/EBP alpha抗体

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持
Phospho-C/EBP alpha (Ser21) Polyclonal Antibody

产品信息

PA5-104915

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-

免疫组化（石蜡） (IHC (P))

1:50-1:200
-

免疫细胞化学 (ICC/IF)

1:100-1:500
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human CEBPA(Accession P49715), corresponding to amino acid residues around phosphorylated Ser21.
查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

sequential chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2816388

产品详细信息

Antibody detects endogenous levels of C/EBP alpha only when phosphorylated at Serine 21.

靶标信息

The C/EBP (CCAAT/enhancer binding protein) family of transcription factors--alpha, beta, delta, and epsilon)--are widely expressed proteins found in a variety of tissues. These domains contain an evolutionarily conserved five-amino acid motif (the regulatory domain motif RDM) that conforms to the consensus sequence (I/V/L) KXEP. One of the major roles of these transcription factors is that of metabolic regulation in liver and fat cells. Studies suggest that these transcription factors act in a cascade aiding in the development of the adipose cell. Three C/EBP beta isoforms (LAP*, LAP, and LIP) arise from different translation initiation and display different function in gene regulation. From a neurological standpoint, C/EBPs have been implicated in the mediation of nerve growth factor, altering synaptic plasticity, and mediation of inflammatory response in AD patients.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

篇参考文献 (0)

您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
引用该产品

生物信息学

蛋白别名: C EBP; C/EBP alpha; CAAT/enhancer-binding protein DNA-binding protein; CAAT/enhancer-binding protein, DNA-binding protein; CCAAT/enhancer binding protein (C/EBP), alpha; CCAAT/enhancer binding protein, alpha; CCAAT/enhancer-binding protein alpha; OTTHUMP00000220269

查看更多 收起

基因别名: C/EBP-alpha; C/ebpalpha; CBF-A; CEBP; CEBPA; DBPCEP

查看更多 收起

UniProt ID: (Human) P49715, (Mouse) P53566, (Rat) P05554

查看更多 收起

Entrez Gene ID: (Human) 1050, (Mouse) 12606, (Rat) 24252

查看更多 收起

功能
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding transcription coactivator activity protein binding transcription factor binding kinase binding protein homodimerization activity transcription regulatory region DNA binding RNA polymerase I regulatory region DNA binding protein domain specific binding protein complex binding histone deacetylase binding sequence-specific DNA binding protein heterodimerization activity HMG box domain binding basic leucine zipper transcription factor
参与通路
urea cycle negative regulation of transcription from RNA polymerase II promoter liver development embryonic placenta development generation of precursor metabolites and energy transcription, DNA-templated transcription from RNA polymerase II promoter mitochondrion organization Notch signaling pathway cholesterol metabolic process negative regulation of cell proliferation viral process cytokine-mediated signaling pathway myeloid cell differentiation macrophage differentiation lung development granulocyte differentiation positive regulation of proteasomal ubiquitin-dependent protein catabolic process glucose homeostasis fat cell differentiation positive regulation of fat cell differentiation positive regulation of osteoblast differentiation negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription from RNA polymerase III promoter cell maturation inner ear development white fat cell differentiation brown fat cell differentiation lipid homeostasis cellular response to lithium ion cellular response to organic cyclic compound regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase I promoter multicellular organism development regulation of cell proliferation negative regulation of cell cycle positive regulation of transcription, DNA-templated acute-phase response response to nutrient cell differentiation organ regeneration response to vitamin B2 response to glucocorticoid
guarantee_icon

性能保障

只要您发现Invitrogen抗体在实验中的表现与网站或说明书的所述内容不符，您即可享受免费退换货服务。*

了解更多
help_icon

随时为您服务

获取常见问题的专家解答，或者直接联系我们的技术专家，咨询应用、设备、常规产品使用问题。

联系技术支持