Rockland

Phospho-CD2AP (Tyr4, Tyr8, Tyr10) Polyclonal Antibody

Name: Phospho-CD2AP (Tyr4, Tyr8, Tyr10) Polyclonal Antibody
Brand: Rockland
SKU: 600-401-J96

查看其他11个CD2AP抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

Immunogen image

Immunogen Image Phospho-CD2AP (Tyr4, Tyr8, Tyr10) Polyclonal Antibody

产品信息

600-401-J96

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:2,000

酶联免疫吸附实验 (ELISA)

1: 10,000

免疫沉淀 (IP)

1 µg/mL

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Anti-CD2AP pY 4-8-10 affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a phosphorylated synthetic peptide at Tyr-4-8-10 at the N-terminal of human CD2AP protein.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

0.02M potassium phosphate, pH 7.2, with 1mg/mL BSA, 50% glycerol, 0.15M NaCl

内含物

0.01% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

A BLAST analysis was used to suggest cross-reactivity with human based on 100% sequence homology. Cross-reactivity with CD2AP from other sources has not been determined.

靶标信息

This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease.

仅用于科研。不用于诊断过程。未经明确授权不得转售。