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Invitrogen
Phospho-CDK7 (Ser164) Polyclonal Antibody
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图: 1 / 8
Phospho-CDK7 (Ser164) Antibody (PA5-105583) in ICC/IF
Immunocytochemistry analysis of Phospho-CDK7 (Ser164) in HepG2 cells (4h of LPS treatment). The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with Phospho-CDK7 (Ser164) polyclonal antibody (Product # PA5-105583) 1:200 and mouse anti-beta tubulin antibody (1:200) for 1 hour at 37°C. An AlexaFluor594 conjugated goat... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-105583
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human CDK7(Accession P50613), corresponding to amino acid residues around phosphorylated Ser164.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of CDK7 only when phosphorylated at Ser164.
靶标信息
The trimeric complex of CDK7, cyclin H and MNAT1, functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This complex is thought to serve as a direct link between the regulation of transcription and the cell cycle. The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). CDK7 may be a target of germline cancer-inducing mutations.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 39 kDa protein kinase; 39 protein kinase; CAK; CDK; CDK-activating kinase; CDK-activating kinase 1; Cell division protein kinase 7; CR4 protein kinase; CRK4; CRK4 PK (CDC2-related-kinase-4 protein kinase); Cyclin-dependent kinase 7; cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase); cyclin-dependent kinase 7 (MO15 homolog Xenopus laevis cdk-activating kinase); cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase); EC 2.7.11.22; EC 2.7.11.23; OTTHUMP00000222032; OTTHUMP00000222033; P39 Mo15; Protein-tyrosine kinase MPK-7; Serine/threonine-protein kinase 1; TFIIH basal transcription factor complex kinase subunit
基因别名: AI323415; AI528512; C230069N13; CAK; CAK1; CDK7; CDKN7; Crk4; MO15; Mpk-7; STK1
UniProt ID: (Mouse) Q03147
Entrez Gene ID: (Rat) 171150, (Mouse) 12572
protein kinase activity
protein serine/threonine kinase activity
cyclin-dependent protein serine/threonine kinase activity
ATP binding
protein C-terminus binding
DNA-dependent ATPase activity
RNA polymerase II carboxy-terminal domain kinase activity
kinase activity
protein complex binding
nucleotide binding
protein binding
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
DNA repair
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
protein phosphorylation
positive regulation of transcription from RNA polymerase II promoter
cell division
meiotic cell cycle
regulation of cell cycle
transcription, DNA-templated
cellular response to DNA damage stimulus
cell cycle
phosphorylation
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