Invitrogen

Phospho-Calcium Sensing Receptor (Thr888) Polyclonal Antibody

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Phospho-Calcium Sensing Receptor (Thr888) Polyclonal Antibody

产品信息

PA5-104889

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-

免疫细胞化学 (ICC/IF)

1:100-1:500
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human CASR(Accession P41180), corresponding to amino acid residues around phosphorylated Thr888.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

sequential chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2816362

产品详细信息

Antibody detects endogenous levels of Calcium Sensing Receptor only when phosphorylated at Threonine 888.

靶标信息

Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G- protein that activates a phosphatidylinositol-calcium second messenger system.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: Ca sensing receptor; calcium-sensing receptor; Calcium-sensing receptor (hypocalciuric hypercalcemia 1 severe neonatal hyperparathyroidism); Calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism); CaR; CaSR; CaSR antibody; cation sensing receptor; Extracellular calcium-sensing receptor; G protein coupled receptor, family C, group 2, member A; G protein-coupled receptor, family C, group 2, member A; parathyroid Ca(2+)-sensing receptor 1; Parathyroid cell calcium-sensing receptor; Parathyroid cell calcium-sensing receptor 1; PCaR1

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基因别名: CAR; CASR; EIG8; FHH; FIH; GPRC2A; HHC; HHC1; HYPOC1; NSHPT; PCAR1

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UniProt ID: (Human) P41180, (Rat) P48442, (Mouse) Q9QY96

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Entrez Gene ID: (Human) 846, (Rat) 24247, (Mouse) 12374

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功能
phosphatidylinositol phospholipase C activity G-protein coupled receptor activity protein binding magnesium ion binding integrin binding calcium ion binding drug binding polyamine binding protein kinase binding ion channel binding signal transducer activity G-protein coupled receptor
参与通路
ossification detection of calcium ion cellular calcium ion homeostasis G-protein coupled receptor signaling pathway chemosensory behavior anatomical structure morphogenesis calcium ion import response to ischemia calcium ion transport apoptotic process adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway JNK cascade positive regulation of cell proliferation response to metal ion positive regulation of gene expression response to organic cyclic compound positive regulation of insulin secretion positive regulation of ATPase activity cellular response to hepatocyte growth factor stimulus vasodilation positive regulation of vasoconstriction branching morphogenesis of an epithelial tube positive regulation of positive chemotaxis response to calcium ion regulation of calcium ion transport fat pad development cellular response to vitamin D cellular response to glucose stimulus cellular response to low-density lipoprotein particle stimulus cellular response to hypoxia response to fibroblast growth factor positive regulation of calcium ion import cellular response to peptide signal transduction
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