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7TM Antibodies
Phospho-Cannabinoid Receptor 1 (Ser425) Polyclonal Antibody
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Phospho-Cannabinoid Receptor 1 (Ser425) Antibody (7TM0056A-IC) in IHC (PFA)
Immunohistochemical identification of Agonist-induced Serine425 phosphorylation of the Cannabinoid Receptor 1 in mouse brain. Mice were either injected intraperitoneally with vehicle or specific CB1 Agonist CP-55940 (0, 75 mg/kg bodyweight) for 30 min. Animals were then transcardially perfused, fixed and stained in presence of phosphatase and protease inhibitors. Shown are confocal images of coronal section... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
7TM0056A-IC
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic phosphopeptide derived from human CB1 around the phosphorylation site of Ser425.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
300 µg
纯化类型
Antigen affinity chromatography
保存液
Dulbecco's PBS, pH 7.4
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Brain-type cannabinoid receptor; CANN6; Cannabinoid receptor 1; CB-R; CB1; CB1 receptor; HGNC:2159; OTTHUMP00000016839; RP1-23D17.1; striatal cannabinoid receptor type 1 protein
基因别名: CB-R; CB1; CB1R; CNR; CNR1; Skr6; SKR6R
UniProt ID: (Mouse) P47746, (Rat) P20272
Entrez Gene ID: (Mouse) 12801, (Rat) 25248
positive regulation of acute inflammatory response to antigenic stimulus
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
axonal fasciculation
aging
learning or memory
memory
positive regulation of neuron projection development
regulation of lipid metabolic process
sensory perception of pain
positive regulation of fever generation
negative regulation of fatty acid beta-oxidation
regulation of synaptic transmission, GABAergic
response to lipopolysaccharide
negative regulation of mast cell activation
negative regulation of dopamine secretion
response to nicotine
cannabinoid signaling pathway
response to cocaine
glucose homeostasis
positive regulation of apoptotic process
negative regulation of ion transport
response to morphine
response to ethanol
negative regulation of action potential
negative regulation of blood pressure
positive regulation of blood pressure
regulation of insulin secretion
negative regulation of nitric-oxide synthase activity
regulation of synaptic transmission, glutamatergic
regulation of feeding behavior
regulation of penile erection
spermatogenesis
response to nutrient
maternal process involved in female pregnancy
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
