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7TM Antibodies
Phospho-Chemokine Receptor 6 (Ser357) Polyclonal Antibody
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Phospho-Chemokine Receptor 6 (Ser357) Antibody (7TM0063A) in WB
Agonist-induced Serine357 phosphorylation of the Chemokine Receptor 6. Upper panel, HEK293 cells stably expressing the Chemokine Receptor 6 (CCR6) were either not exposed or exposed to 100 nM specific Chemokine receptor 6 Agonist CCL20 for 30 minutes. Cells were lysed and immunoblotted with the anti-pS357-CCR6 antibody (7TM0063A) at a dilution of 1:1,000. Lower panel, blot was stripped and reprobed with an ... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
7TM0063A
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic phosphopeptide derived from human CCR6 around the phosphorylation site of Ser357.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
Dulbecco's PBS, pH 7.4
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
CD196, also known as CCR6, is a member of the beta chemokine receptor family and is characterized by a seven transmembrane structure similar to G protein-coupled receptors. This receptor uniquely binds to macrophage inflammatory protein 3 alpha (MIP-3alpha/CCL20), which acts as a chemoattractant for dendritic cells, effector/memory T cells, and B cells. CCR6 is preferentially expressed by immature dendritic cells and memory T cells, playing a crucial role in host defense and inflammation at epithelial sites. It is important for B-lineage maturation and antigen-driven B-cell differentiation, and it regulates the migration and recruitment of dendritic and T cells during inflammatory and immunological responses. Additionally, CCR6 has been implicated in the differentiation of Th17 cells and the development of CD4+FoxP3+ regulatory T cells, highlighting its role in immune regulation. Alternatively spliced transcript variants encoding the same protein have been described for this gene, further emphasizing its functional diversity in immune processes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C-C chemokine receptor type 6; C-C CKR-6; CD196; Chemokine receptor-like 3; CKR-L3; CKR6; DRY-6; DRY6; G-protein coupled receptor 29; GPR-CY4; GPRCY4; LARC receptor
基因别名: CCR6; CKRL3; CMKBR6; GPR29; STRL22
Entrez Gene ID: (Human) 1235
Disclaimer
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