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Invitrogen

Phospho-ERK1/ERK3 (Thr202, Thr185) Recombinant Rabbit Monoclonal Antibody (K01_4Q55)

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产品信息

MA567633

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:1,000
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

HEK293F

分类

Recombinant Monoclonal

类型

Antibody

克隆号

K01_4Q55

抗原

A synthesized peptide derived from human Phospho-ERK1 (T202) + ERK2 (T185).

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

规格

100 µg

纯化类型

Protein A/G

保存液

PBS, pH 7.4, with 50% glycerol, 150mM NaCl, 0.05% BSA

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

ERK1 and ERK3 are members of the extracellular signal regulated kinase family within the mitogen activated protein kinase network. ERK1 is encoded by MAPK3 and functions as a classical kinase activated by the Ras Raf MEK cascade, controlling transcription factor activity, cell cycle progression, proliferation, differentiation, and survival through cytoplasmic and nuclear substrates. ERK3 is encoded by MAPK6 and is an atypical kinase with a distinct activation mechanism that relies on phosphorylation and protein stability, often forming complexes with MK5 also known as PRAK to regulate cell motility and stress responses. ERK1 exhibits robust oscillatory activation and nuclear shuttling upon growth factor stimulation, whereas ERK3 shows constitutive or context dependent regulation and subcellular localization patterns that differ from ERK1 and ERK2. Both kinases are implicated in cancer biology, developmental processes, and inflammatory signaling, and are evaluated with gene expression assays, phospho specific immunodetection, and functional studies using small molecule inhibitors or genetic perturbations.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: ERK-1; ERK-3; Erk-3 related; Erk1; cancer susceptibility protein; ERK1b; ERK1c; ERT2; Extracellular signal-regulated kinase 1; Extracellular signal-regulated kinase 3; extracellular signal-regulated kinase, p97; extracellular signal-related kinase 1; Insulin-stimulated MAP2 kinase; MAP kinase 1; MAP kinase 3; MAP kinase 6; MAP kinase isoform p44; MAP kinase isoform p97; MAPK 1; MAPK 3; MAPK 6; Microtubule-associated protein 2 kinase; mitogen activated protein kinase 4; mitogen activated protein kinase 6; mitogen-activated 3; mitogen-activated protein kinase 1; Mitogen-activated protein kinase 3; Mitogen-activated protein kinase 6; MNK1; p44 MAP kinase; p44-ERK1; p44-MAPK; p55-MAPK; p97-MAPK; pp42/MAP kinase; PRKM1; PRKM6; protein kinase, mitogen activated kinase 4; protein kinase, mitogen-activated 5; protein kinase, mitogen-activated 6; unnamed protein product

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基因别名: 2610021I23Rik; D130053K17Rik; ERK-1; ERK1; ERK3; ERT2; Esrk1; HS44KDAP; HsT17250; HUMKER1A; MAPK1; MAPK3; Mapk4; MAPK6; Mapk63; MNK1; Mtap2k; p44; p44-ERK1; p44-MAPK; P44ERK1; P44MAPK; p97MAPK; PRKM3; Prkm4; PRKM6

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UniProt ID: (Human) P27361, (Human) Q16659, (Rat) P21708, (Mouse) Q63844, (Mouse) Q61532, (Rat) P27704

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Entrez Gene ID: (Human) 5595, (Human) 5597, (Rat) 50689, (Mouse) 26417, (Mouse) 50772, (Rat) 58840

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功能
nucleotide binding phosphotyrosine binding protein kinase activity protein serine/threonine kinase activity MAP kinase activity protein binding ATP binding kinase activity transferase activity phosphatase binding identical protein binding protein serine kinase activity DNA-binding transcription factor binding protein kinase binding protein heterodimerization activity scaffold protein binding transferase activity, transferring phosphorus-containing groups non-receptor serine/threonine protein kinase
参与通路
autophagosome assembly MAPK cascade negative regulation of T cell mediated immune response to tumor cell transcription, DNA-templated protein phosphorylation apoptotic process cellular response to DNA damage stimulus cell surface receptor signaling pathway epidermal growth factor receptor signaling pathway insulin receptor signaling pathway organ morphogenesis regulation of gene expression negative regulation of autophagy positive regulation of autophagy positive regulation of macrophage chemotaxis neural crest cell development Schwann cell development phosphorylation sensory perception of pain regulation of ossification BMP signaling pathway regulation of cellular pH thyroid gland development positive regulation of cyclase activity lipopolysaccharide-mediated signaling pathway cellular response to nutrient levels positive regulation of telomere maintenance negative regulation of proteasomal ubiquitin-dependent protein catabolic process response to lipopolysaccharide regulation of stress-activated MAPK cascade cellular response to amino acid starvation intracellular signal transduction peptidyl-tyrosine autophosphorylation ERBB2-ERBB3 signaling pathway TORC1 signaling outer ear morphogenesis myelination glucose homeostasis signal transduction in response to DNA damage response to exogenous dsRNA positive regulation of transcription from RNA polymerase II promoter insulin-like growth factor receptor signaling pathway thymus development modulation of synaptic transmission protein stabilization negative regulation of T cell activation cartilage development stress-activated MAPK cascade regulation of cytoskeleton organization Bergmann glial cell differentiation face development lung morphogenesis trachea formation cardiac neural crest cell development involved in heart development interleukin-34-mediated signaling pathway ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade interleukin-1-mediated signaling pathway response to epidermal growth factor cellular response to mechanical stimulus cellular response to tumor necrosis factor caveolin-mediated endocytosis regulation of Golgi inheritance negative regulation of cholesterol efflux xenophagy positive regulation of macrophage proliferation positive regulation of neuroinflammatory response negative regulation of TORC1 signaling positive regulation of xenophagy regulation of early endosome to late endosome transport signal transduction positive regulation of dendritic spine development MAPK import into nucleus positive regulation of protein phosphorylation protein complex assembly DNA damage induced protein phosphorylation response to toxic substance peptidyl-serine phosphorylation arachidonic acid metabolic process positive regulation of histone phosphorylation positive regulation of histone acetylation positive regulation of translation positive regulation of transcription, DNA-templated regulation of sequence-specific DNA binding transcription factor activity negative regulation of apolipoprotein binding cell cycle
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