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          • Primary Antibodies ›
          • EphA2/EphA3/EphA4 Antibodies

          Invitrogen

          Phospho-EphA2/EphA3/EphA4 (Tyr588, Tyr596) Polyclonal Antibody

          查看其他3个EphA2/EphA3/EphA4抗体

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          Cite Phospho-EphA2/EphA3/EphA4 (Tyr588, Tyr596) Polyclonal Antibody

          Additional Information:
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          • 抗体检测数据 (2)
          Phospho-EphA2/EphA3/EphA4 (Tyr588, Tyr596) Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.
          Phospho-EphA2/EphA3/EphA4 (Tyr588, Tyr596) Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.

          图: 1 / 2

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          Phospho-EphA2/EphA3/EphA4 (Tyr588, Tyr596) Antibody (PA5-37811) in ICC/IF

          Immunocytochemical analysis of Phospho-EphA2/EphA3/EphA4 (Tyr588, Tyr596) in methanol-fixed Hela cells, using Phospho-EphA2/EphA3/EphA4 (Tyr588, Tyr596) Polyclonal Antibody (Product # PA5-37811). {{ $ctrl.currentElement.advancedVerification.fullName }} 验证信息 View more
          已发表图片由___提供 benchsci-logo
          PMID: {{$ctrl.currentElement.benchSciPubmedId}}
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          Phospho-EphA2/EphA3/EphA4 (Tyr588, Tyr596) Antibody in Immunocytochemistry (ICC/IF)
          Phospho-EphA2/EphA3/EphA4 (Tyr588, Tyr596) Antibody in Western Blot (WB)
          Phospho-EphA2/EphA3/EphA4 (Tyr588, Tyr596) Polyclonal Antibody

          产品信息

          PA5-37811

          应用
          建议稀释比
          已发表文章

          免疫印迹 (WB)

          1:500-1:1,000
          -

          免疫细胞化学 (ICC/IF)

          1:100-1:200
          -
          产品规格

          种属反应

          Human, Mouse

          宿主/亚型

          Rabbit / IgG

          分类

          Polyclonal

          类型

          Antibody

          抗原

          Peptide sequence around phosphorylation site of tyrosine 588/596 (K-T-Y(p)-V-R)/(R-T-Y(p)-V-D) derived from Human EPHA2/3/4.
          查看免疫原

          偶联物

          Unconjugated Unconjugated Unconjugated

          形式

          Liquid

          浓度

          1 mg/mL

          纯化类型

          Antigen affinity chromatography

          保存液

          PBS, pH 7.4, with 50% glycerol

          内含物

          0.02% sodium azide

          保存条件

          -20°C

          运输条件

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2554419

          产品详细信息

          A suggested positive control for Western blot is HepG2 cells; suggested positive control for ICC/IF is Hela cells.

          靶标信息

          The Eph subfamily represents the largest group of receptor protein tyrosine kinases identified to date. While the biological activities of these receptors have yet to be determined, there is increasing evidence that they are involved in central nervous system function and in development. The Eph subfamily receptors of human origin (and their murine/avian homologs) include EphA1(Eph), EphA2 (Eck), EphA3 (Hek4), EphA4 (Hek8), EphA5 (Hek7), EphA6 (Hek12),EphA7 (Hek11/MDK1), EphA8 (Hek3), EphB1 (Hek6), EphB2 (Hek5), EphB3(Cek10, Hek2), EphB4 (Htk), EphB5 (Hek9) and EphB6 (Mep). Ligands for Eph receptors include ephrin-A4 (LERK-4) which binds EphA3 and EphB1. In addition, Ephrin-A2 (Elf-1) has been described as the ligand for EphA4, ephrin-A3 (Ehk1-L) as the ligand for EphA5 and ephrin-B2 (Htk-L) as the ligand for EphB4 (Htk).

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

          篇参考文献 (0)

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          引用该产品

          生物信息学

          蛋白别名: EK4; EK8; EPH-like kinase 4; EPH-like kinase 8; Eph-like tyrosine kinase 1; Ephrin A2; Ephrin A3; Ephrin A4; Ephrin type-A receptor 2; Ephrin type-A receptor 3; Ephrin type-A receptor 4; EphrinA2; EphrinA3; EphrinA4; Epithelial cell kinase; epithelial cell receptor protein tyrosine kinase; HEK; Human embryo kinase; human embryo kinase 1; receptor protein-tyrosine kinase HEK8; soluble receptor; testicular tissue protein Li 64; TYRO1 protein tyrosine kinase; TYRO4 protein tyrosine kinase; Tyrosine-protein kinase receptor ECK; Tyrosine-protein kinase receptor ETK1; Tyrosine-protein kinase receptor MPK-3; Tyrosine-protein kinase receptor MPK-5; Tyrosine-protein kinase receptor SEK; Tyrosine-protein kinase receptor SEK-1; Tyrosine-protein kinase receptor SEK-2; Tyrosine-protein kinase TYRO1; Tyrosine-protein kinase TYRO4; unnamed protein product

          查看更多 收起

          基因别名: 2900005C20Rik; AI385584; ARCC2; AW492086; AW545284; Cek4; Cek8; CTPA; CTPP1; CTRCT6; ECK; EK4; EK8; End3; EPHA2; EPHA3; EPHA4; ETK; ETK1; HEK; HEK4; HEK8; Mek4; Myk2; rb; SEK; Sek-2; Sek1; Sek2; TYRO1; TYRO4

          查看更多 收起

          UniProt ID: (Human) P29317, (Human) P29320, (Human) P54764, (Mouse) Q03145, (Mouse) Q03137

          查看更多 收起

          Entrez Gene ID: (Human) 1969, (Human) 2042, (Human) 2043, (Mouse) 13836, (Mouse) 13837, (Mouse) 13838

          查看更多 收起

          功能
          nucleotide binding virus receptor activity protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity ephrin receptor activity protein binding ATP binding kinase activity transferase activity growth factor binding cadherin binding molecular function activator activity GPI-linked ephrin receptor activity transmembrane-ephrin receptor activity beta-amyloid binding PH domain binding identical protein binding ephrin receptor binding DH domain binding protein tyrosine kinase binding transferase activity, transferring phosphorus-containing groups transmembrane signal receptor
          参与通路
          skeletal system development angiogenesis blood vessel development vasculogenesis osteoblast differentiation negative regulation of cytokine production blood vessel endothelial cell proliferation involved in sprouting angiogenesis apoptotic process response to stress inflammatory response cell adhesion transmembrane receptor protein tyrosine kinase signaling pathway intrinsic apoptotic signaling pathway in response to DNA damage regulation of lamellipodium assembly notochord formation cell migration negative regulation of angiogenesis neural tube development central nervous system neuron differentiation cell differentiation regulation of cell adhesion keratinocyte differentiation osteoclast differentiation regulation of cell migration positive regulation of cell migration epithelial cell differentiation negative regulation of chemokine production mammary gland epithelial cell proliferation regulation of cell adhesion mediated by integrin post-anal tail morphogenesis regulation of blood vessel endothelial cell migration regulation of angiogenesis cAMP metabolic process viral entry into host cell bone remodeling ephrin receptor signaling pathway axial mesoderm formation animal organ development blood vessel morphogenesis notochord morphogenesis cell motility defense response to Gram-positive bacterium notochord cell development cell chemotaxis branching involved in mammary gland duct morphogenesis lens fiber cell morphogenesis regulation of ERK1 and ERK2 cascade response to growth factor protein localization to plasma membrane activation of GTPase activity negative regulation of lymphangiogenesis positive regulation of protein localization to plasma membrane positive regulation of bicellular tight junction assembly pericyte cell differentiation axon guidance regulation of epithelial to mesenchymal transition positive regulation of neuron projection development peptidyl-tyrosine phosphorylation regulation of actin cytoskeleton organization regulation of GTPase activity negative regulation of endocytosis regulation of focal adhesion assembly regulation of microtubule cytoskeleton organization cellular response to retinoic acid fasciculation of sensory neuron axon fasciculation of motor neuron axon deadenylation-dependent decapping of nuclear-transcribed mRNA negative regulation of cell adhesion nervous system development adult walking behavior motor neuron axon guidance positive regulation of cell proliferation glial cell migration negative regulation of epithelial to mesenchymal transition negative regulation of neuron projection development negative regulation of translation corticospinal tract morphogenesis negative regulation of cell migration adherens junction organization negative regulation of neuron apoptotic process positive regulation of cell adhesion negative regulation of translational initiation positive regulation of JNK cascade negative regulation of axon regeneration regulation of astrocyte differentiation regulation of axonogenesis positive regulation of dendrite morphogenesis protein stabilization innervation regulation of dendritic spine morphogenesis negative regulation of ERK1 and ERK2 cascade nephric duct morphogenesis cochlea development neuron projection guidance synapse pruning neuron projection fasciculation membraneless organelle assembly negative regulation of cellular response to hypoxia negative regulation of long-term synaptic potentiation positive regulation of beta-amyloid formation positive regulation of intracellular signal transduction positive regulation of amyloid precursor protein catabolic process negative regulation of proteolysis involved in cellular protein catabolic process cellular response to beta-amyloid regulation of modification of synaptic structure regulation of synapse pruning protein phosphorylation phosphorylation neuron differentiation protein kinase B signaling negative regulation of protein kinase B signaling positive regulation of establishment of protein localization to plasma membrane endocardial cushion development multicellular organism development positive regulation of JUN kinase activity protein autophosphorylation positive regulation of Rho guanyl-nucleotide exchange factor activity
          It has to be done as per old AB suggested Products section.

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