Invitrogen

Phospho-EphB1/EphB3/EphB4 (Tyr778, Tyr792, Tyr774) Polyclonal Antibody

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说明书
实验方案
问题与答案
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Phospho-EphB1/EphB3/EphB4 (Tyr778, Tyr792, Tyr774) Polyclonal Antibody

产品信息

PA5-105950

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000-1:3,000
-

免疫组化（石蜡） (IHC (P))

1:50-1:200
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human EPHB1(Accession P54762), corresponding to amino acid residues around phosphorylated Tyr778.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

sequential chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2817349

产品详细信息

Antibody detects endogenous levels of EPH B1/3/4 only when phosphorylated at Tyr778/792/774.

靶标信息

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. EphB4 binds to ephrin-B2 and plays an essential role in vascular development.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Developmental kinase 2; Developmental kinase 5; EK2; EK6; ELK; ELK-related protein tyrosine kinase; Embryonic kinase 2; Eph receptor B2 (ELK-related protein tyrosine kinase); EPH receptor B4; EPH tyrosine kinase 2; EPH-like kinase 2; EPH-like kinase 6; EPH-like tyrosine kinase 2; EPH-like tyrosine kinase-2; ephrin receptor EphB4; Ephrin type-B receptor 1; Ephrin type-B receptor 3; Ephrin type-B receptor 4; Hepatoma transmembrane kinase; human embryo kinase 2; mDK-2; mDK-5; NET; Neuronally-expressed EPH-related tyrosine kinase; soluble EPHB1 variant 1; soluble EPHB4 variant 1; soluble EPHB4 variant 2; soluble EPHB4 variant 3; Tyrosine kinase MYK-1; Tyrosine-protein kinase receptor EPH-2; tyrosine-protein kinase receptor HTK; Tyrosine-protein kinase receptor SEK-4; Tyrosine-protein kinase TYRO11; Tyrosine-protein kinase TYRO6

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基因别名: 9330129L11; AI042935; AW456895; AW488255; C130099E04Rik; Cek10; Cek6; EK2; ELK; Elkh; ENSMUSG00000074119; EPHB1; Ephb2; EPHB3; EPHB4; EPHT2; Epth2; Erk; ETK2; HEK2; HEK6; HTK; MDK2; MDK5; MYK1; NET; Sek4; TYRO11; TYRO6

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UniProt ID: (Human) P54762, (Human) P54753, (Human) P54760, (Rat) P09759, (Mouse) Q8CBF3, (Mouse) P54754, (Mouse) P54761

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Entrez Gene ID: (Human) 2047, (Human) 2049, (Human) 2050, (Rat) 24338, (Mouse) 270190, (Mouse) 13845, (Rat) 287989, (Rat) 686310, (Mouse) 13846

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功能
transmembrane-ephrin receptor activity protein binding ATP binding axon guidance receptor activity protein complex binding ephrin receptor activity transmembrane receptor protein tyrosine kinase activity protein tyrosine kinase activity nucleotide binding protein kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups transmembrane signal receptor
参与通路
angiogenesis immunological synapse formation axon guidance peptidyl-tyrosine phosphorylation optic nerve morphogenesis central nervous system projection neuron axonogenesis neurogenesis establishment of cell polarity retinal ganglion cell axon guidance cell-substrate adhesion regulation of JNK cascade protein autophosphorylation ephrin receptor signaling pathway camera-type eye morphogenesis detection of temperature stimulus involved in sensory perception of pain positive regulation of synapse assembly cell chemotaxis dendritic spine development dendritic spine morphogenesis neural precursor cell proliferation regulation of ERK1 and ERK2 cascade regulation of neuron death urogenital system development axonal fasciculation cell migration corpus callosum development regulation of cell-cell adhesion substrate adhesion-dependent cell spreading regulation of GTPase activity thymus development digestive tract morphogenesis regulation of axonogenesis palate development cell migration involved in sprouting angiogenesis heart morphogenesis cell adhesion cranial nerve development protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway nervous system development phosphorylation signal transduction multicellular organism development
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