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Invitrogen
Phospho-Ephrin B1 (Tyr313, Tyr317) Polyclonal Antibody
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Phospho-Ephrin B1 (Tyr313, Tyr317) Antibody (PA5-105608) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded Phospho-Ephrin B1 (Tyr313, Tyr317) in mouse heart tissue sections. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with Phospho-Ephrin B1 (Tyr313, Tyr317) polyclonal antibody (Product # PA5-105608) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
产品信息
PA5-105608
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human EFNB1(Accession P98172), corresponding to amino acid residues around phosphorylated Tyr313.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of EFNB1 only when phosphorylated at Tyr313/317.
靶标信息
Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CEK5 receptor ligand; CEK5-L; CEL5-L; EFL-3; EFL6; EFNB3; ELK ligand; ELK-L; EPH-related receptor tyrosine kinase ligand 2; Ephrin B3; Ephrin-B1; Ephrin-B1 precursor; EphrinB1; EPLG8; kinase ephrin-B1; LERK-2; LERK8; Stimulated by retinoic acid gene 1 protein; STRA1 protein
基因别名: Cek5-L; CFND; CFNS; EFB1; EFL-3; EFL3; EFNB1; Elk-L; Epl2; EPLG2; LERK-2; LERK2; Stra1
UniProt ID: (Human) P98172, (Mouse) P52795
Entrez Gene ID: (Human) 1947, (Rat) 25186, (Mouse) 13641
